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Research focus:  

C 3-Prof. für Klin. u. exp. Osteologie
Brettreichstrasse 11, D-97074 Würzburg
Mail: f-jakob.klh@mail.uni-wuerzburg.de
Url: http://www.uni-wuerzburg.de/orthopaedie/

Scientific members:

   Professors:

   Outside lecturer:

   Scientific assistants:

Research foci (and basic equipment-based research projects):
- Clinical Research Unit "Osteogenic Stem Cell Differentiation and Therapy of Bone Loss"; Research Director: Prof. Dr. J. Eulert; Principal Investigator in Chief: Prof. Dr. F. Jakob; Principal Investigators: Prof. Dr. W. Sebald (associated, Head of Department of Phys. Chemistry II), PD Dr. N. Schütze, Dr. U. Nöth);
- Rekombinant Proteins (PD Dr. N. Schütze)
- Genomics and Proteomics of the Stem Cell (Dr. R. Ebert, Dr. K. Paunescu)
- Tissue Engineering and Mesenchymal Stem Cells (Dr. U. Nöth)
- Particle Disease and Differential Gene Expression (PD Dr. C. Rader)
- Clinical Studies on Bisphosphonates in Osteoporosis and Paget´s Disease (Prof. Dr. F. Jakob, Dr. H. Freyberger, Dr. F. Merklein)

Results:
Results are shown in single project reports.

Rewards and prizes:
Lechner A., Schütze N., Siggelkow H., Seufert J., Jakob F. (2000) "The immediate early gene product hCYR61 localises to the secretory pathway in human osteoblasts". Bone 27:53-60 Nomination for the "Best Paper Award" 2000 in "Bone" by the International Society for Bone and Mineral Research.
Päth G., Jakob F., Royer S., Roller J., and Seufert J. Development of Strategies for Identification, Isolation and Expansion of Human Pancreatic Endocrine Intra-Islet Stem Cells. Poster Award of the German Diabetes-Association (DDG), 37. Annual Meeting, Dresden, May 08.-11., 2002.
Rader C., Baumann B., Schütze N., Jakob F., Eulert J. (2001) "Regulation of Gene products in a human Particle-Disease-Model" 1. Poster Award of the Association of Orthopedic Surgeons in North Germany e.V.
Schütze N., Lechner A., Müller J., Eulert J., Jakob F. Expression and regulation of the immediate early gene product hCYR61 in human osteoblasts. "Mario Boni Award" 2000 of the European Orthopedic Research Society
Schütze N., Reichel S., Barthelmes U., Rücker N., Pfeufer J., Lechner A., Jakob F. (2001) "The human Protein A kinase adaptor protein 2 is a TNFalpha regulated gene in human osteoblasts and localizes to the actin cytoskeleton". Plenary Poster bei der Jahrestagung der American Society for Bone and Mineral Research, Phoenix, USA
Schütze N: Travel Award Annual Meeting of osteologic Societies "Osteologie 2002", Graz, Austria
Ebert R: Travel Award Annual Meeting of osteologic Societies "Osteologie 2002", Graz, Austria
Seufert J., Dorfner B., Netzer D., Jakob F. Expression and functional characterization of the homeodomain transcription factor PDX-1 in gastrin producing human antral cells. Posterpreis 2000 der Deutschen Gesellschaft für Endokrinologie
Seufert J., Laubner K., Jakob F. Signalling and gene regulation by leptin in pancreatic beta-cells involves suppressor of cytokine signalling 3 (SOCS 3). Posterpreis 2000 der Sektionen Neuroendokrinologie/ Diabetes und Stoffwechsel der Deutschen Gesellschaft für Endokrinologie
Seufert, J., K. Laubner, S. Royer, J. Roller, T.J. Kieffer, and F. Jakob. Proinsulin gene transcription activation by synergistic interactions of STAT5b and the homeodomain protein IDX-1 with the CBP/p300 coactivator in pancreatic beta-cells. "Merck Senior Fellows Award" der Endocrine Society, USA; 83rd Annual Meeting of The Endocrine Society (ENDO 2001), Denver, Colorado
Seufert, J., K. Laubner, T.J. Kieffer, and F. Jakob. Leptin mediated signal transduction in pancreatic beta-cells".Travel Grant Award" der American Diabetes Association (ADA), Meeting in Philadelphia,
Seufert, J., M. Gehlen, A. Knoll, and F. Jakob. P8 is a novel nuclear protein associated with pancreatic beta-cell proliferation. "Travel Grant Award" der Endocrine Society, USA; 82nd Annual Meeting of The Endocrine Society 2000,Toronto, Canada.
Seufert, J., M. Gehlen, A. Knoll, J. Roller, S. Royer, and F. Jakob. Kontrollierte Expansion von Insulin produzierenden beta-Zellen. Posterpreis der Deutschen Gesellschaft für Innere Medizin (DGIM), 107. Jahrestagung, Wiesbaden, 22.-25. April 2001

Equipment:
Laboratories comprising tools for basic science research under conditions of S1, partly allowance for radioactivity.
Apparitve Laboratory equipment: Light-Cycler, Phosphor-Imager, FPLC-Equipment, Automatic Sequencer, Fluorescence Microscopy

Links:
Institute for Experimental Endocrinology, Charité Berlin
DFG Research Program Selenoproteins
DFG Graduate Program 639
IZKF University of Würzburg
GSF Munich