Regulation of Cell Growth: Project: Regulators of proliferation and cell death of lymphocytes
Project management at the University of Würzburg:
There are two very important phases in which lymphocyte death is induced.1) during selection processes which lead to the elimination of autoreactive cells and following activation, when supernumerary cells are eliminated by death receptor dependent apoptosis. In the studies supported by the Graduate College we found that A1, an antiapoptotic member of the bcl-2 family, allows autoreactive cells to escape deletion following antigen receptor engagement. A1 is induced by CD40 Ligation and protects B cells by preventing mitochondrial damage. Elevated levels of A1 also seems to contribute to the prolonged survival of antigen experienced T cells in IL-2 deficient mice, but is not the sole contributory factor to the complex and multifactorial disease manifestations observed in these animals.
Projekt period: from 04.1999 to 03.2002
DFG ,Granting date: 01.11.1998