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Third-party-funded project

Title:
Tolerance and immunity in congenital Toxoplasmosis of the rat

Project management at the University of Würzburg:

• Prof. Dr. Thomas Herrmann ,Tel: 0931-20149955,Fax: 0931-20149243,Mail: herrmann-t@vim.uni-wuerzburg.de

Participating scientists:

• MD Juan-Carlos Sepulveda-Arias , bis 12/02
• Dipl. Biol. Stefan Wiehr , ab 8/02

Abstract:
Toxoplasmosis is on the most common infections by parasite. It is of great clinical importance in its congenital form. We use the strong similarity of toxplasmosis in rats and human for testing mechanism of control of the disease in an animal model. To this end LEW and F344 are studied, which in akute adult toxoplasmosis show differences in the course of the infection. Our interest is especially focused on the immune response of the infected offspring with respect to in utero induced immunity or tolerance to T. gondii or T. gondii antigens and a deviation of the immune response (TH1/TH2 shift).

Key words:
    congenital toxoplasmosis
    Tolerance
    animal model
    infection

Projekt period: from 01.2000 to 12.2003

Funding institution:
DFG

Preceding project:
Spezifität und Aktivierung von NK und gd T Zellen der Ratte: Bedeutung für die Infektabwehr

Publications:

• J.C. Sepulveda ?Arias, T. Herrmann. (2002). T-cell unresponsiveness in rats congenitally infected with the parasite Toxoplasma gondii. Immunobiology 206:198, (scientific article)
• J.C. Sepulveda ?Arias, M.C. Kempf, D. Wedekind, H.J. Hedrich, M.F. Cesbron-Delauw, U. Gross, T. Herrmann. (2002). The atyhmic LEW-Whn10rnu rat as a model to study T cell independent mechanism of resistance against T. gondii.. Immunobiology 206:198, (scientific article)
• J.C. Sepulveda ?Arias, T. Herrmann. (2002). Studies on the immune response in rats infected with Toxoplasma gondii via maternal milk. Immunobiology 206:199, (scientific article)

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