Tolerance and immunity in congenital Toxoplasmosis of the rat
Project management at the University of Würzburg:
Toxoplasmosis is on the most common infections by parasite. It is of great clinical importance in its congenital form. We use the strong similarity of toxplasmosis in rats and human for testing mechanism of control of the disease in an animal model. To this end LEW and F344 are studied, which in akute adult toxoplasmosis show differences in the course of the infection. Our interest is especially focused on the immune response of the infected offspring with respect to in utero induced immunity or tolerance to T. gondii or T. gondii antigens and a deviation of the immune response (TH1/TH2 shift).
Projekt period: from 01.2000 to 12.2003
Spezifität und Aktivierung von NK und gd T Zellen der Ratte: Bedeutung für die Infektabwehr