Increased interleukin (IL) 4 receptor expression and IL-4-induced decrease in
IL-12 production by Langerhans cells infected with Leishmania major
Project management at the University of Würzburg:
Langerhans cells (LC) take up Leishmania major and are critical for induction of the parasite-specific T cell response. Their functional activities are regulated by cytokines. We analyzed whether infection of LC with L. major modulates their cytokine receptor expression. The expression of interleukin (IL) 4 receptor was increased on infected LC from susceptible mice but not on those from resistant mice. Moreover, IL-4 treatment strongly decreased the lipopolysaccharide-induced IL-12 response of infected LC from susceptible mice. This modulation of IL-4 receptor expression and IL-12 production by infection of LC with Leishmania may contribute to the development of Th2 cells and susceptibility to infection.
Projekt period: from 01.1997 to 06.2000