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Analysis of the interaction between Aspergillus fumigatus and human immune effector cells and the induction of innate and adaptive immune responses to this pathogen

Projektleitung an der Universität Würzburg:

Beteiligte Wissenschaftlerinnen und Wissenschaftler:


Host defense is a paramount in invasive aspergillosis (IA) and thus, a better understanding of the induction of innate and adaptive immune responses to Aspergilli is mandatory for the development of immunotherapeutic strategies.

Therefore, we are aiming for the identification of Aspergillus-specific PAMPs and the corresponding PRRs on dendritic cells, alveolar macrophages and granulocytes. Different maturation forms of A. fumigatus, various Aspergillus mutants, non-fumigatus species as well as a wide range of recombinant proteins expressed in our HEK293 cell system will be used to define signalling pathways. As read-out systems, transcriptomics, proteomics and flow cytometry will be performed. Relevant genes will be further studied for genetic polymorphisms and their possible role as genetic risk factors for IA. Furthermore, we will perform a comprehensive analysis of clinically relevant immunosuppressive agents on the function of the immune effector cell populations mentioned above. Results of these experiments might allow a modification of immunosuppression to better preserve antifungal immune functions especially in high risk patients for IA.

Laufzeit: von 06.2006 bis 12.2008