The role of epigenetic modifications in multiple myeloma, a potentially new treatment option
Project management at the University of Würzburg:
Epigenetic modifications like DNA methylation and histone deacetylation are known to down regulate expression of tumor suppressor genes in malignant cells. The modulation of epigenetic modifications by inhibitors can lead to re-expression of genes associated with growth arrest, apoptosis and can sensitize cells toward chemotherapeutic substances. The first clinical trials with these substances are under way. In case of multiple myelom not much is known about the role of epigenetic modifications and their role for the malignant phenotype. Aim of this study is to first characterize the effect of inhibitors of DNA methylation and histon deacetylation on growth and survival of multiple myeloma cells and subsequently identify the molecular mechanisms mediating these effects. These experiments might lead the foundation for further clinical trials.
Projekt period: from 06.2005 to 06.2007
Sonstige Stiftung ( Wilhelm Sander-Stiftung )