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Third-party-funded project

Title:
HIT 2000: Randomized multicentric prospective phase-III-trial for the treatment of children and adolescents with intracranial PNET/Medulloblastoma and Ependymoma.

Project management at the University of Würzburg:

Participating scientists:

Abstract:
The prospective multicenter trial HIT 2000 for treatment of children and young adults with an intracranial primitive neuroectodermal tumor (PNET/Medulloblastoma) and Ependymoma is conducted at the children?s hospital of the University of Wuerzburg. Primary aims are to increase the probabilitity of PFS and EFS of study patients by intensified chemotherapy and/or radiotherapy, by risk-adapted therapy for exactly defined risk-groups and by improvement of quality control. Further aims are to reduce late sequelae by reduction or substitution of radiotherapy in younger children with medulloblastoma. A randomized phase-III trial is designed to investigate if patients from 4-21 years of age without metastasis can reach an increased PFS by a hyperfractionated radiotherapy regimen compared to a conventional radiotherapy regimen with a reduced craniospinal dosis. A national reference center for CSF-analysis in children with malignant brain tumors has been established. Neuropsychological studies are conducted to determine residual deficiencies and quality of life of children with medulloblastoma.

Key words:
    Medulloblastoma/PNET/Ependymoma/chemotherapy

Projekt period: from 01.2001 to 12.2005

Funding institution:
Sonstige Stiftung ( Deutsche Kinderkrebsstiftung ) ,Granting date: 29.05.2001

Preceding project:
Therapiestudie HIT 91

Publications: