Lehrstuhl für Kinderheilkunde
Josef-Schneider-Str. 2, 97080 Würzburg
Research foci (and basic equipment-based research projects):
Outcome of preterm infants is determined by immaturity and additional risk factors such as chorioamnionitis. We have shown that bronchopulmonary dysplasia is associated with a chronic pulmonary inflammation which can originate from chorioamnionitis and can be sustained by mechanical ventilation or oxygen toxicity. In addition to prenatal inflammation the preterm baby is at risk for postnatal infection and inflammation. We have shown that Cytomegalovirus infection is reactivated in lactating mothers and infection can be transmitted via breast milk. In addition, we have shown that oxygen consumption varies in the postnatal period and plays a major part in neonatal oxygen tolerance and sensitivity. Effective radiation therapy is necessary to minimize oxygen consumption for which new radiation systems are under development and evaluation.