Lehrstuhl für Kinderheilkunde
Josef-Schneider-Str. 2, 98080 Würzburg
Research foci (and basic equipment-based research projects):
One major focus of this research group was the evaluation of exercise testing as a tool for diagnosis and follow-up in patients with chronic health conditions, such as cystic fibrosis, thyroid carcinoma, and HLA B27-positive arthritis.
In a second focus, the effects of physical training on exercise capacity and lung functions in patients with cystic fibrosis were determined. An international multicenter approach was employed to set-up a randomized, controlled trial which is coordinated from Würzburg and Zürich.
A third area of research was related to the development of novel techniques in the diagnosis and follow-up of pulmonary disease in cystic fibrosis. Using measurements of transepithelial potential difference in the nasal mucosa, several factors impacting on the function of the CFTR-chloride channel and the amiloride-sensitive sodium channel were identified. In several studies, performed in cooperation with the institute of radiology and the institute of physics of Würzburg university, the validity and reliability of pulmonary MRI was assessed in cystic fibrosis.