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Research focus:  

Lehrstuhl für Kinderheilkunde
Josef-Schneider-Str. 2, 97080 Würzburg
Mail: schlegel@mail.uni-wuerzburg.de
Url: http://www.kinderklinik.uni-wuerzburg.de

Scientific members:

   Professors:

   Scientific assistants:

   Other participating persons and organisations:

Research foci (and basic equipment-based research projects):
Our group has focused on key questions related to the transplantation of human and murine hematopoietic stem cells : Following the transplantation of highly purified haploidentical or matched unrelated stem cells we and others have observed a phase of immune incompetence until the new T-cell repertoire evolves. We have analyzed the kinetics of immune reconstitution of T-, NK- and B-cell compartments. Our special focus of attention is the molecular analysis of the reemerging T-cell compartment by CDR3-size spectratyping and TREC assays. In parallel to the work on human stem cells, we have established a mouse transplantation model that allows to prospectively study the mechanisms of T-cell expansion within different target organs.