Lehrstuhl für Kinderheilkunde
Josef-Schneider-Str. 2, 97080 Würzburg
Other participating persons and organisations:
Research foci (and basic equipment-based research projects):
Our group has focused on key questions related to the transplantation of human and murine hematopoietic stem cells : Following the transplantation of highly purified haploidentical or matched unrelated stem cells we and others have observed a phase of immune incompetence until the new T-cell repertoire evolves. We have analyzed the kinetics of immune reconstitution of T-, NK- and B-cell compartments. Our special focus of attention is the molecular analysis of the reemerging T-cell compartment by CDR3-size spectratyping and TREC assays. In parallel to the work on human stem cells, we have established a mouse transplantation model that allows to prospectively study the mechanisms of T-cell expansion within different target organs.