Third-party-funded project
Title:
Immunomodulation with IL-4/IL-13 inhibitors in a mouse model for allergic asthma
Project management at the University of Würzburg:
Participating scientists:
Abstract:
The project studies the therapeutic potential of immunomodulation with a self contructed IL-4/IL-13 inhibtor in a murine asthma model. Read out parameters are Th1/Th2 polarisation, IgE synthesis and allergic lung pathology.
Key words:
atopy
immunomodulation
cytokine inhibitor
Projekt period:
from 01.2000 to 12.2002
Funding institution:
DFG ( Graduiertenkolleg Immunmodulation ) ,Granting date: 01.01.2000
Publications:
- Nelde, A., Teufel, M., Hahn, C., Duschl, A., Sebald, W., Bröcker, E. B. and Grunewald, S. M.
(2001). The impact of route and frequency of antigen exposure on IgE response in allergy. Int Arch Allergy Immunol, (scientific article)
- Grunewald, S.M.., Hahn, C., Wohlleben G.,Teufel, M., Major, T., Moll, H., Bröcker, E.B., Erb, K.
(2002). Infection with Influenza A virus leads to flu antigen induced cutaneous anaphylaxis in mice. J Invest Dermatol, (scientific article)
- Nelde, A., Teufel, M., Hahn, C., Duschl, A., Sebald, W., Bröcker, E.B., Grunewald, S.M..
(2000). The impact of route, dose and frequency of antigen exposure on the IgE response in allergy. In Immunobiology . (conference publication)
- Hahn, C., Teufel, M., Sebald, W., Duschl,A., Bröcker, E.B., Grunewald. S.M.
(2001). Inhibition of the IL-4/IL-13 receptor system in a mouse model for allergic asthma. In Immunobiology . (conference publication)
- Hahn, C., Teufel, M., Erb, K.J., Bröcker, E.B., Duschl, A , Grunewald, S.M.
(2002). IL-4 and IL-4 receptor alpha chain independent IgE synthesis in an allergy model in mice. In Arch Dermatol Res . (conference publication)
