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Third-party-funded project

Title:
The role of mitogenic and stress-induced MAP kinase pathways in the regulation of keratinocyte proliferation and differentiation.

Project management at the University of Würzburg:

• Professor Dr. rer. nat. Stephan Ludwig , Institut für Medizinische Strahlenkunde und Zellforschung (MSZ), Universität Würzburg
• PD Dr. med. Matthias Goebeler

Participating scientists:

• Dipl. Biol. Marc Schmidt , (bis 31. 08. 2001)
• Magister (Biologie) Martin Giner , (seit 01. 01. 2002)
• Dr. med. Cornelia Seitz

Abstract:
siehe Forschungsschwerpunkt AG Goebeler

Key words:
    keratinocyte
    proliferation
    differentiation
    calcium
    Raf/MEK/Erk
    NF-kappaB

Projekt period: from 04.1997 to 12.2003

Funding institution:
DFG ( LU 477/3-1 ) ,Granting date: 18.07.2001
DFG ( LU 477/3-2 )
DFG ( LU 477/3-3 )

Preceding project:
DFG LU 477/3-1 und LU 477/3-2

Publications:

• Schmidt, M. et al.. (2000). Ras-independent activation of the Raf/MEK/ERK pathway upon calcium-induced differentiation of keratinocytes.. J Biol Chem 275, 41011-41017 (2000), (scientific article)
• Schmidt, M. et al.. (2001). Selective expression of calcium-binding proteins S100A8 and S100A9 at distinct sites of hair follicles.. J Invest Dermatol 117, 748-750 (2001), (scientific article)
• Roth, J. et al.. (2001). S100A8 and S100A9 in inflammatory diseases.. The Lancet 357, 1041 (2001), (scientific article)
• Pasparakis, M. et al.. (2002). TNF-mediated skin diisease in mice with epidermis-specific deletion of IKK2.. Nature 417, 861-866 (2002), (scientific article)