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Third-party-funded project

Title:
Intracellular signalling pathways in endothelium and their impact on recruitment of leukocytes

Project management at the University of Würzburg:

• PD Dr. med. Matthias Goebeler
• Profesor Dr. rer. nat. Stephan Ludwig , Institut für Medizinische Strahlenkunde und Zellforschung (MSZ) der Universität Würzburg

Participating scientists:

• Dr. rer. nat. Beate Hess

Abstract:
siehe Forschungsschwerpunkt AG Goebeler

Key words:
    endothelium
    chemokines
    intracellular signalling pathways
    NF-kappa B
    p38 MAP kinase
    allergic contact dermatitis

Projekt period: from 05.1999 to 05.2003

Funding institution:
DFG ( GO 811/1-1 ) ,Granting date: 27.11.2000
DFG ( GO 811/1-3 )
Sonstige öffentliche Mittel ( Fonds der Chemischen Industrie )

Preceding project:
DFG GO 811/1-3

Publications:

• Ludwig, S. et al.. (1998). The stress inducer arsenite activates mitogen activated protein kinases ERK1/2 via a MKK6/p38 dependent pathway.. J Biol Chem 273, 1917-1922 (1998), (scientific article)
• Goebeler, M. et al.. (1999). The MKK6/p38 stress kinase cascade is involved in TNF--induced expression of monocyte chemoattractant protein-1 in endothelial cells.. Blood 93, 857-865 (1999), (scientific article)
• Hippenstiel, S. et al.. (2000). Rho proteins and p38-MAPK pathway are important mediators for LPS-induced interleukin-8 expression in human endothelial cells.. Blood 95, 3044-3051 (2000), (scientific article)
• Goebeler, M. et al.. (2001). Multiple signaling pathways regulate NF-kappaB-dependent transcription of the monocyte chemoattractant protein-1 (MCP-1) gene in primary endothelial cells.. Blood 97, 46-55 (2001), (scientific article)
• Goebeler, M. et al.. (2001). Sequential expression of multiple chemokines during elicitation of allergic contact dermatitis.. Am J Pathol 158, 431-440 (2001), (scientific article)
• Denk, A. et al.. (2001). Activation of NF-kappaB via the IkappaB kinase complex is both essential and sufficient for proinflammatory gene expression in primary endothelial cells.. J Biol Chem 276, 28451-28458 (2001), (scientific article)
• Roth, J. et al.. (2001). Homocysteine inhibits tumor necrosis factor-induced activation of endothelium via modulation of nuclear factor-kappaB activity.. Biochim Biophys Acta 1540, 154-165 (2001), (scientific article)
• Gillitzer, R. und Goebeler, M.. (2001). Chemokines in cutaneous wound healing.. . J Leukoc Biol 69, 513-521 (2001), (scientific article)
• Koch, H. G. et al.. (1998). The redox status of aminothiols as a clue to homocysteine induced vascular damage.. In Eur J Pediatr 157 (Suppl. 2), S102-S106 (1998) . (meeting publication)

Links:
PubMed