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Third-party-funded project

Title:
Characterization of functionally relevant epitopes on the ectodomain of the 180 kD bullous pemphigoid autoantigen (BP180/type XVII collagen)

Project management at the University of Würzburg:

Participating scientists:

Abstract:
In addition to the binding of autoantibodies, the inflitration of inflammatory cells and the release of various inflammatory mediators, including interleukin 6 and 8, is necessary for blister formation in bullous pemphigoid. In this study, we demonstrated for the first time that keratinocytes, by secreting interleukin 6 and 8 upon stimulation with patients autoantibodies, actively contribute to the inflammatory process finally leading to blister formation in bullous pemphigoid.

Key words:
    interleukin 8
    interleukin 6
    bullous pemphigoid
    BP180
    type XVII collagen

Projekt period: from 01.1998 to 04.1999

Funding institution:
Bund ( IZKF Würzburg ) ,Granting date: 01.12.1998

Publications: