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Third-party-funded project

Title:
Characterisation of autoantibodies to BP180/type XVII collagen: Correlation with the clinical phentype of autoimmune blistering diseases

Project management at the University of Würzburg:

Participating scientists:

Abstract:
Autoantibodies to hemidesmosomal constituents induce subepidemal blisters in the skin. An important component of hemidesmosomes is the 180 kD bullous pemphigoid antigen (BP180/type XVII collagen). Our studies addressed the question, if different autoantibody specifitities induce different clinical phenotypes in the patients. We produced overlapping recombinant peptides of the immunodominant NC16A region of the BP180 ectodomain und developd different ELISA systems to detect antibodies to BP180. Our results show that both the binding of autoantibodies to distinct epitopes on BP180 and the immunoglobulin subclass of the autoantibody determine disease expression. Diseases associated wit autoantibodies to BP180 include bullous pemphigoid, pemphigoid gestationis, lichen planus pemphigoides, linear IgA disease, and mucous membrane pemphigoid. Our results lead to a more precise classification of autoimmune subepidermal bullous diseases which should be helpful for developing better treatment strategies for the different diseases.

Key words:
    Type VII collagen
    BP180
    Pemphigoid

Projekt period: from 05.1999 to 04.2001

Funding institution:
Sonstige öffentliche Mittel ( Wilhelm Sander-Stiftung ) ,Granting date: 25.01.1999

Publications: