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Research focus:  

Lehrstuhl für Haut- und Geschlechtskrankheiten
Josef-Schneider-Str. 2, 97080 Würzburg
Mail: zillikens_d@klinik.uni-weurzburg.de
Url: http://www.hautklinik.uni-wuerzburg.de

Scientific members:

   Professors:

   Scientific assistants:

   Other participating persons and organisations:

Research foci (and basic equipment-based research projects):
Humoral and cellular pathogenesis of cutaneous autoimmune diseases

Results:
Bullous autoimmune skin diseases are characterized by circulating and tissue-bound autoantibodies to structural components of the skin. These proteins are important for cell-cell and cell-matrix adhesion. Binding of autoantibodies to their target antigen in the skin leads to intra- or subepidermal blisters. Our laboratory studies different pathophysiological aspects that are associated with these diseases using molecular, cell biological, and immunological techniques. The different projects focus on interaction of extracellular matrix proteins, their importance for signal transduction and cell migration as well as the characterization of humoral and cellular immune mechanisms contributing to blister formation. The increased knowledge on the the pathogenesis of these conditions is being used to develop novel diagnostic and therapeutic tools for these severe diseases.

Equipment:
Our laboratory and the shared research facilities of the Department of Dermatology have all the equipment to perform our projects as outlined below.