research report      name index      key word index      corresp.unit            Page in german      Imprint + Privacy Policy   

Third-party-funded project

Title:
Influence of Different Autotransfusion-Devices on the Quality of Salvaged Blood.

Project management at the University of Würzburg:

Participating scientists:

Abstract:
Cardiopulmonary bypass (CPB) causes a systemic inflammatory response and impaired hemostasis. We investigated, if intraoperative blood salvage with the cardiotomy suction contributes to these alterations. Furthermore, an alternative autotransfusion device (Haemonetics cell saver) was examined.
In ten patients interleukin(IL)-6, IL-8, tumor necrosis factor-a (TNF-a), thrombin-antithrombin complex (TAT), plasmin-antiplasmin complex (PAP), free hemoglobin (fHb) and the percentage of CD62+ thrombocytes were determined in the systemic circulation during CPB, in the cardiotomy suction tube and in the Haemonetics blood. Additionaly, bacterial contamination was examined.
It could be observed that cardiotomy suction additionally contributes to the release of proinflammatory cytokines, activation of coagulation and hemolysis. Since blood salvage with a Haemonetics cell saver led to normalization of some, but not all parameters and bacterial contamination was common, the alternative use seems at least questionable.

Key words:
    CABG
    cardiotomy suction
    inflammation
    hemostasis

Projekt period: from 01.1999 to 12.1999

Publications: