Lehrstuhl für Klin.Biochemie und Pathobiochemie
Versbacher Str. 5, 97078 Würzburg
Research foci (and basic equipment-based research projects):
A central goal of the chair of clinical biochemistry is the elucidation of inter- and intracellular signal transduction pathways that are involved in the inhibition of cardiovascular cells, i.e. cardiac myocytes, vascular smooth muscle cells, endothelial cells, platelets, and inflammatory cells. A major focus is the analysis of ANF / NO / cGMP signal transduction pathways and particularly the role of cGMP-dependent protein kinases and their substrate VASP (Vasodilator-stimulated phosphoprotein). It is expected that the elucidation of these pathways will contribute to a better understanding of pathogenesis and useful therapeutic interventions of major cardiovascular diseases, i.e. hypertension, arteriosclerosis, coronary heart disease, and heart failure. Other research areas include platelet receptors, tumor suppressor genes, and the cell and molecular biology of the cytoskeleton.
see Institute of Clinical Biochemistry and Pathobiochemistry