C3-Professur für Klinische Molekularbiologie (Prof. Dr.rer.nat. M. Zimmer)
Versbacher Str. 5, 97078 Würzburg
Research foci (and basic equipment-based research projects):
The group is interested in genetics of cardiovascular diseases, using genetic linkage studies to identify mutated genes and risk factors. Mendelian inheritance is relatively rare in respect to cardiovascular diseases, but the identification of responsible genes is a central information to understand the pathobiochemistry. Morever, the same genes could also play a role in complex forms of cardiovascular diseases, e.g. hypertension, arteriosclerosis and heart insufficiency. Among monogenic diseases we are mainly interested in dilated cardiomyopathy (DCM). In collaboration with the Medical Clinic we recruit new families with DCM and identify mutated genes by positional cloning. Apart from genetic predisposition complex cardiovascular diseases are also determined by environmental factors and life stile. Thus, genetic analysis becomes more complicated and requires new methods and strategies. Single Nucleotide Polymorphisms (SNPs) are a novel class of genetic markers and are of central importance in the analysis. It is the goal of the group to establish and develop new technologies for SNP-typing.