Steroid hormone receptors in mitochondria
Project management at the University of Würzburg:
Steroid hormones regulate the transcription of nuclear genes by way of their cognate receptors (transcriptional factors). In addition, these hormones also modulate mitochondrial gene transcription, particularly of the OXPHOS genes by mechanisms which are as yet poorly understood. We have demonstrated the presence of steroid hormone receptors in the mitochondria and of hormone responsive elements in the mitochondrial genome. Our results support the concept of a receptor-mediated direct action of steroid hormones. Presently, we investigate the involvement of the receptors in the "cross-talk" between the cell nucleus and the mitochondria.
Projekt period: from 01.1998 to 01.2002
Sonstige private Mittel ( Spende )
Zusammenarbeit mit dem Biochemischen Institut der Universität Athen (C.E. Sekeris)