Integrated pest management: the use of insect neuropeptides
Project management at the University of Würzburg:
Insects and other invertebrates are as well ? or even better ? supplied with neuropeptides as mammals. In insects, neuropeptides regulate not only the function of endocrine glands, but also most physiological and developmental processes. The last decades have brought remarkable advances in the field of comparative neuropeptide research and the comparative approach paved the way for the discovery of many novel peptide structures, as well as a few of their receptors. Comparative endocrinologists, however, are not merely interested in the primary structure of novel neuropeptides and peptide hormones, but in the molecular evolution of their precursor and receptor families, in the mechanisms of biosynthesis and release of the peptides/hormones, and in the mechanisms of action at their cellular and molecular levels. We have focused on the prothoracotropic hormone (PTTH) and corazonin in Galleria mellonella and could chracterize the molecular structure of both neuropeptides. We are presently investigating the function of both neurohormones as an essential requirement for developing a new generation of insecticides based on blocking the receptors of the neurohormones.
Projekt period: from 05.2000 to 04.2003
Sonstige öffentliche Mittel ( DLR )