Role of chromosomal non-histone proteins HMGN1 and HMGN2 in cellular differentiation processes and embryonic development
Project management at the University of Würzburg:
Differential gene expression is the fundamental principle of cellular differentiation and embryonic development. An important role to establish this principle is brought about by the structure and composition of the chromatin. Non-histone chromatin components like the HMGN1 and HMGN2 proteins may influence gene expression. Only little is known about the role of these proteins in embryonic development and cellular differentiation. This project is aimed to clarify whether HMGN1 and HMGN2 influence differential gene expression. This is analyzed in vivo with the help of transfected cultured cells and by investigation of the functional role of these proteins during embryonic development of Xenopus laevis. Furthermore, it is planned to identify and characterize proteins that interact with or that modify HMGN1/N2 proteins.
Projekt period: from 01.2000 to 01.2003
DFG ( HO 1804/2-1 ) ,Granting date: 29.07.1999