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Third-party-funded project

Title:
Comparison of antimicrobial and cytotoxic systems of protozoa and their molecular mechanisms with those of other organisms

Project management at the University of Würzburg:

• Prof. Dr Matthias Leippe ,Tel: 0931-312151,Fax: 0931-312578,Mail: matthias.leippe@mail.uni-wuerzburg.de

Participating scientists:

• Dr. Heike Bruhn ,Tel: 0931-312474,Fax: 0931-312578,Mail: heike.bruhn@mail.uni-wuerzburg.de
• Dr. Rosa Herbst
• Dipl. Biotechnol. (FH) Maren Rudolph ,Tel: 0931-312127,Fax: 0931-312578,Mail: maren.rudolph@mail.uni-wuerzburg.de
• Snighda Gosh ,Tel: 0931-312127,Fax: 0931-312578,Mail: snighda.gosh@mail.uni-wuerzburg.de

Abstract:
The biological role and function of different pore-forming proteins of Entamoeba histolytica and other pathogenic amoeba is under investigation. Archaic cytolytic and antimicrobial mechanisms of free-living and pathogenic protozoa is compared with those of higher eukaryotes (e.g. cytolytic and antimicrobial effector proteins of porcine and human cytotoxic lymphocytes).

Key words:
    Amoebapores
    cytolytic and antimicrobial mechanisms of free-living protozoa
    granulysin

Projekt period: from 09.2000 to 09.2003

Funding institution:
DFG ,Granting date: 12.07.2000

Preceding project:
.

Publications:

• Bruhn H, Leippe M.. (2000). Novel putative saposin-like proteins of Entamoeba histolytica different from amoebapores. Biochim. Biophys. Acta, (scientific article)
• Nickel R, Jacobs T, Urban B, Scholze H, Bruhn H, Leippe M.. (2000). Two novel calcium-binding proteins from cytoplasmic granules of the protozoan parasite Entamoeba histolytica. FEBS Lett., (scientific article)
• Herbst R, Ott C, Jacobs T, Marti T, Marciano-Cabral F, Leippe M.. (2002). Pore-forming polypeptides of the pathogenic protozoon Naegleria fowleri. J. Biol. Chem., (scientific article)