Title:
Requirements and molecular mechanisms involved in persistence of parasites within the host - the molecular repertoire of rhoptry organelles in Plasmodium falciparum
Project management at the University of Würzburg:
Participating scientists:
Abstract:
Upon invasion into human erythrocytes, Plasmodium initiates formation of a membrane which creates a unique compartment, the parasitophorous vacuole membranes (PVM), in which the parasite resides in the host cell. Apical secretory organelles of Plasmodium (rhoptries) are presumably involved in biogenesis and maintenance of the PVM. The major issue of this project is the analysis of the molecular repertoire of isolated rhoptries and of PVM of Plasmodium falciparum by two-dimensional polyacrylamide gel electrophoresis combined with MALDI-TOF. We hope to identify key components of the PVM mediating functions vital for the parasite (transport of nutrients into the vacuole, export of host cell modulating components).
Key words:
Plasmodium falciparum
rhoptry organelles
persistence
Projekt period: from 11.2000 to 10.200
Funding institution:
DFG ,Granting date: 17.01.2000