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Third-party-funded project

Title:
Development of a new generation of life vaccine carriers: Brucella, Salmonella and Yersinia

Project management at the University of Würzburg:

• Prof. Dr. Werner Goebel ,Tel: +49-931-888 4400,Fax: +49-931-888 4402,Mail: goebel@biozentrum.uni-wuerzburg.de

Participating scientists:

• PD Dr. Ivalyo Gentschev
• Prof. Dr. Jürgen Kreft
• PD Dr. Gernot Geginat , Universität Heidelberg, Klinikum Mannheim

Abstract:
The capacity of recombinant Brucella, Salmonella and Yersinia to present foreign antigens in the context of different MHC classes has been investigated systematically

Key words:
    Life vaccine carriers
    Brucella, Salmonella, Yersinia

Projekt period: from 10.1998 to 09.2000

Funding institution:
EU ,Granting date: 30.09.1998

Publications:

• Rüßmann, H., Weissmüller, A., Geginat, G., Igwe, E.I., Roggenkamp, A., Bubert, A., Goebel, W., Hof, H., Heesemann, J.. (2000). Yersinia enetrocolitica-mediated translocation of defined fusion proteins to the cytosol of mammalian cells results in peptide-specific MHC class I-restricted antigen presentation. (monograph)
• Spreng, S., Gentschev, I., Goebel, W., Weidinger, G., ter Meulen, V., Niewiesk, S.. (2000). Salmonella vaccines secreting measles virus epitopes induce protective immunity responses against measles virus encephalitis. (monograph)

Links:
Homepage Microbiology