Third-party-funded project
Title:
Molecular strategies for adaptation and survival: Postgenomic analysis of the lifestyles of Listeria monocytogenes in the environment and the infected host
Project management at the University of Würzburg:
- Prof. Dr. Werner Goebel
,Tel: +49-931-888 4400,Fax: +49-931-888 4402,Mail: goebel@biozentrum.uni-wuerzburg.de
- Prof. Dr. Jürgen Kreft
, stellv. Projektleiter,Tel: +49-931-888 4419,Fax: +49-931-888 4402,Mail: kreft@biozentrum.uni-wuerzburg.de
Participating scientists:
- PhD Biju Joseph
,Tel: +49-931-888 4413,Fax: +49-931-888 4402,Mail: biju@biozentrum.uni-wuerzburg.de
- PhD Shubha Gopal
,Tel: +49-931-888 4415,Fax: +49-931-888 4402,Mail: shubha@biozentru.uni-wuerzburg.de
- Dipl.-Biol. Karin Knuth
,Tel: +49-931-888 4416,Fax: +49-931-888 4402,Mail: karin.knuth@biozentru.uni-wuerzburg.de
- M.Sc. Qin Luo
,Tel: +49-931-888 4416,Fax: +49-931-888 4402,Mail: luo@biozentru.uni-wuerzburg.de
- Dipl.-Biol. Barbara Gareiß
,Tel: +49-931-888 4421,Fax: +49-931-888 4402,Mail: b.gareiss@biozentrum.uni-wuerzburg.de
Abstract:
Using transcriptome and proteome analysis as well as mutant construction and their functional analysis in vitro and in cell culture models, the global transcriptional and translational pattern of pathogenic Listeria as well as the role of transcription and other factors is studied under different conditions. The role of these components in the infection process is investigated using culture methods.
Key words:
Listeria
Transcriptome
Proteome
Mutant analysis
Projekt period:
from 02.2000 to 07.2003
Funding institution:
EU ,Granting date: 24.01.2000
Preceding project:
EU BIO4-CT-1998-0036
Publications:
- Daniels, J.J, Autenrieth, I.B., Goebel, W..
(2000). Interaction of L. monocytogenes with the intestinal epithelium. (monograph)
- Kärst, U., REALIS consortium.
(2001). REALIS: Postgenomic analysis of Listeria monocytogenes. (monograph)
- Vazquez-Boland, J.A., Kuhn, M., Berche, P., Chakraborty, T., Dominguez-Bernal, G., Goebel, W., Gonzalez-Zorn, B., Wehland, J., Kreft, J..
(2001). Listeria pathogenesis and molecular virulence determinants. (monograph)
Links:
Homepage Microbiology
