Title:
Perception of extra- and intracellular signals by the unorthodox BvgAS two-component system of Bordetella spp. and linkage of the virulence regulon to metabolic and stress response genes
Project management at the University of Würzburg:
Participating scientists:
Abstract:
The aim of the project is the understanding of the complex processes which lead to a regulatory linkage of the virulence regulon to important housekeeping functions in Bordetella pertussis and related organisms. The BvgAS two-component system controls the coordinate expression of the virulence genes, but also, possible mediated by the BvgAS-activated BvgR repressor protein, several important housekeeping genes encoding dehydrogenases, transport systems and cytochrome oxidases. Our recent data indicate that the histidine kinase BvgS is able to perceive and possibly also to integrate extra- and intracellular stimuli. The signal perception mechanisms by this unusual histidine kinase will be investigated.
Key words:
Bordetella
signal transduction
BvgS
histidine kinase
Projekt period: from 06.2002 to 05.2004
Funding institution:
DFG
Preceding project:
DFG GR1243/2-4
Publications: