Forschungsschwerpunkt: |
Lehrstuhl für Anorganische Chemie I
Am Hubland, 97074 Würzburg Mail: r.tacke@mail.uni-wuerzburg.de Url: http://www-anorganik.chemie.uni-wuerzburg.de/tacke/index.html |
Wissenschaftliche Mitglieder:
Professoren:
Wissenschaftliche Mitarbeiter:
Forschungsschwerpunkte (und Projekte auf Basis der Grundausstattung):
Synthese, Struktur und Reaktivität von Organosilicium-Verbindungen (Schwerpunkt: Organosilicium-Verbindungen mit funktionellen Gruppen am Silicium-Atom und/oder an den Organyl-Resten);
Synthese, Struktur und Reaktivität von Organogermanium-Verbindungen;
Optisch aktive Organosilicium-Verbindungen mit Silicium als Chiralitätszentrum (Entwicklung von Synthesemethoden, chiroptische Charakterisierung).
Ergebnisse:
Publikationen in 2003
1) R. Tacke, V.I. Handmann, R. Bertermann, C. Burschka, M. Penka, C. Seyfried; Sila-analogues of high-affinity, selective σ ligands of the spiro[indane-1,4´-piperidine] type: syntheses, structures, and pharmacological properties.
Organometallics 22, 916-924 (2003).
2) R. Tacke, T. Schmid, M. Hofmann, T. Tolasch, W. Francke; Sila-linalool as a pheromone analogue: a study on C/Si bioisosterism.
Organometallics 22, 370-372 (2003).
3) R. Bertermann, N. Kröger, R. Tacke; Solid-state 29Si MAS NMR studies of dia-toms: structural characterization of biosilica deposits.
Anal. Bioanal. Chem. 375, 630-634 (2003).
4) R. Tacke, R. Bertermann, A. Biller, C. Burschka, M. Penka; Chemistry of zwit-terionic pentacoordinate silicon compounds of the (ammoniomethyl)bis- [gly-colato(2─)-O1,O2]silicate type.
Can. J. Chem. 81, 1315-1325 (2003).
5) S. Duda-Johner, J.O. Daiß, K. Mohr, R. Tacke; Synthesis and pharmacologi-cal characterization of new silicon-based W84-type allosteric modulators for ligand binding to muscarinic M2 receptors.
J. Organomet. Chem. 686, 75-83 (2003).
6) O. Seiler, R. Bertermann, N. Buggisch, C. Burschka, M. Penka, D. Tebbe, R. Tacke; Hexacoordinate silicon(IV) complexes containing thiocyanato-N ligands ─ syntheses, structural characterization, and computational studies.
Z. Anorg. Allg. Chem. 629, 1403-1411 (2003).
7) R. Bertermann, A. Biller, M. Kaupp, M. Penka, O. Seiler, R. Tacke; New zwit-terionic spirocyclic λ5Si-silicates with an SiX4C skeleton (X = S, O) containing two ligands of the dithiolato(2─) or diolato(2─) type: synthesis, structure, and bonding situation.
Organometallics 22, 4104-4110 (2003).
8) T. Schmid, J.O. Daiss, R. Ilg, H. Surburg, R. Tacke; Enantiopure chiral deriva-tives of the fragrance materials majantol and sila-majantol: a bioisosteric car-bon/silicon switch with drastic effects on the sensory characteristics.
Organometallics 22, 4343-4346 (2003).
9) R. Tacke, R. Bertermann, M. Penka, O. Seiler; Bis[acetylacetonato(1─)-O,O]di(cyanato-N)silicon(IV): a neutral hexacoordinate silicon complex with two cyanato-N ligands.
Z. Anorg. Allg. Chem. 629, 2415-2420 (2003).
10) R. Tacke, O. Seiler; Higher-coordinate silicon compounds with SiO5 and SiO6 skeletons.
Silicon Chemistry: From the Atom to Extended Systems (Eds.: P. Jutzi, U. Schubert), pp. 324-337, Wiley-VCH, Weinheim 2003.
11) W. Bains, R. Tacke; Silicon chemistry as a novel source of chemical diversity in drug design.
Curr. Opin. Drug Disc. Dev. 6, 526-543 (2003).
12) R. Tacke, J. Daiss (Amedis Pharmaceuticals Ltd.); Silicon compounds.
PCT Int. Pat. Appl. WO 03/037905 A1 (08.05.2003); Chem. Abstr. 138, 354097d (2003).
13) R. Tacke, T. Heinrich (Amedis Pharmaceuticals Ltd.); Silicon compounds.
UK Pat. Appl. GB 2382575 A (04.06.2003); Chem. Abstr. 139, 7019k (2003).
14) R. Tacke, I. Richter (Julius-Maximilians-Universitaet Wuerzburg); Higher-coordinate silicates.
PCT Int. Pat. Appl. WO 03/061640 A1 (31.07.2003); Chem. Abstr. 139, 154995 (2003).
15) R. Tacke, V.I. Handmann (Julius-Maximilians-Universität Würzburg, R. Tacke); Silicon derivatives of amino acids.
PCT Int. Pat. Appl. WO 03/082880 A1 (09.10.2003); Chem. Abstr. 139, 292499 (2003).
Publikationen in 2004
1) O. Seiler, M. Penka, R. Tacke; [Benzilato(2─)-O1,O2]bis[1,3-diphenylpropane-1,3-dionato(1─)-O,O]silicon(IV): a neutral heteroleptic hexacoordinate sili-con(IV) complex with an SiO6 skeleton.
Inorg. Chim. Acta 357, 1955-1958 (2004).
2) T. Heinrich, C. Burschka, J. Warneck, R. Tacke; Synthesis and pharmacologi-cal properties of silicon-containing 1,4-dihydropyridine derivatives: calcium channel antagonists and α1 adrenoceptor antagonists of the sila-niguldipine type.
Organometallics 23, 361-366 (2004).
3) R. Tacke, T. Heinrich, R. Bertermann, C. Burschka, A. Hamacher, M.U. Kassack; Sila-haloperidol: a silicon analogue of the dopamine (D2) re-ceptor antagonist haloperidol.
Organometallics 23, 4468-4477 (2004).
4) T. Heinrich, C. Burschka, M. Penka, B. Wagner, R. Tacke; 4-Silapiperidine and 4-silapiperidinium derivatives: syntheses and structural characterization.
J. Organomet. Chem., im Druck.
5) J.O. Daiß, K. Barth, C. Burschka, P. Hey, R. Ilg, K. Klemm, I. Richter, S.A. Wagner, R. Tacke; Synthesis of the multifunctional (chloromethyl)silanes Cl2Si(CH2Cl)2, (MeO)2Si(CH2Cl)2, RSi(CH2Cl)3 (R = 2,4,6-trimethoxyphenyl), ClSi(CH2Cl)3, MeOSi(CH2Cl)3, Si(CH2Cl)4, and ClCH2CH2Si(CH2Cl)3.
Organometallics, im Druck.
6) J.O. Daiß, M. Penka, C. Burschka, R. Tacke; The Si-2,4,6-trimethoxyphenyl moiety as a novel protecting group in organosilicon chemistry: alternative syn-thesis of rac-sila-venlafaxine.
Organometallics, im Druck.
7) R. Tacke, T. Schmid, M. Penka, C. Burschka, W. Bains, J. Warneck; Synthe-ses and pharmacological properties of the histaminic H1 antagonists sila-terfenadine-A, sila-terfenadine-B, disila-terfenadine, and sila-fexofenadine: a study on C/Si bioisosterism.
Organometallics, im Druck.
8) J.O. Daiß, C. Burschka, R. Tacke; ß-Carbonylsilanes with a silacyclohexane skeleton and additional C-functionalized organyl groups at the silicon atom: synthesis, reactivity, and NMR-spectroscopic characterization.
J. Organomet. Chem., im Druck.
9) J.O. Daiß, M. Albrecht, K. Mohr, R. Tacke, A novel silicon-based uncharged allosteric modulator for ligand binding to muscarinic M2 receptors: synthesis and pharmacological characterization.
Organometallics, im Druck.
10) R. Tacke, R. Bertermann, C. Burschka, S. Dragota, M. Penka, I. Richter, R. Willeke; Spirocyclic zwitterionic 5Si-silicates with two bidentate ligands de-rived from -amino acids or -hydroxycarboxylic acids: synthesis, structure, and stereodynamics.
J. Am. Chem. Soc., im Druck.
11) R. Tacke, R. Bertermann, C. Burschka, S. Dragota; Hexacoordinate silicon(IV) complexes with SiO6 skeletons and multidentate ligands derived from citric acid or malic acid.
Z. Anorg. Allg. Chem., im Druck.
12) O. Seiler, M. Fischer, M. Penka, R. Tacke; Synthesis and structural charac-terization of novel neutral hexacoordinate silicon(IV) complexes with SiO2N4 skeletons.
Organosilicon Chemistry VI ? From Molecules to Materials (Eds.: N. Auner, J. Weis), Wiley-VCH, Weinheim, im Druck.
13) J.O. Daiß, B. Müller, C. Burschka, W. Bains, J. Warneck, R. Tacke; Ligands of the 1,4?-silaspiro[tetralin-1,4?-piperidine] type and the seroto-nin/noradrenaline reuptake inhibitor sila-venlafaxine: studies on C/Si bio-isosterism.
Organosilicon Chemistry VI ? From Molecules to Materials (Eds.: N. Auner, J. Weis), Wiley-VCH, Weinheim, im Druck.
14) R. Tacke, T. Schmid (Amedis Pharmaceuticals Ltd.); Piperidinyl-diarylsilanol compounds and their use in therapy.
UK Pat. Appl. GB 2394714 A (05.05.2004).
15) J.G. Montana, I. Fleming, R.Tacke, J. Daiss (Amedis Pharmaceuticals Ltd.); Heterocyclic silicon compounds and their use in the treatment of diseases or conditions associated with GnRH (gonadotropin-releasing hormone).
PCT Int. Pat. Appl. WO 2004/045625 A1 (03.06.2004).
16) J.G. Montana, G.A. Showell, I. Fleming, R.Tacke, J. Daiss (Amedis Pharma-ceuticals Ltd.); Silicon compounds.
PCT Int. Pat. Appl. WO 2004/048390 A1 (10.06.2004).
17) J.G. Montana, G.A. Showell, R.Tacke (Amedis Pharmaceuticals Ltd.); Silicon compounds to be used as ligands for retinoid receptors.
PCT Int. Pat. Appl. WO 2004/048391 A1 (10.06.2004).
18) R. Tacke, T. Heinrich (Amedis Pharmaceuticals Ltd.); Silicon compounds.
UK Pat. Appl. GB 2396863 A (07.07.2004).
19) R. Tacke, J. Daiss, G.A. Showell, A. Richards (Amedis Pharmaceuticals Ltd.); Silicon compounds.
UK Pat. Appl. GB 2397576 A (28.07.2004).