Investigations on the Structure and Biosynthesis of Antidesmone from Antidesma membranaceum (Euphorbiaceae)
Project management at the University of Würzburg:
Feeding experiments with cell cultures revealed the structure of a novel glycine-derived acetogenic quinoline alkaloid from Antidesma membranaceum, which had originally been described as an isoquinoline alkaloid. Antidesmone is built up mainly from acetate units, the nitrogen-containing part, however, originates from glycine. Furthermore, antidesmone shows promising activities against Trypanosoma cruzi, which is the vector of Chagas disease.
Acetogenic Natural Products
Glycine-Derived Quinoline Alkaloid
from 01.1999 to 12.2002
Sonstige Stiftung ( Max-Buchner-Forschungsstiftung )
- G. Bringmann, J. Schlauer, H. Rischer, M. Wohlfarth, R. Haller, S. Bär, R. Brun.
(2001). Antidesmone, a Novel Antitrypanosomal Alkaloid. (monograph)
- G. Bringmann, H. Rischer, M. Wohlfarth, J. Schlauer.
(2000). Biosynthesis of Antidesmone in Cell Cultures of Antidesma membranaceum (Euphorbiaceae): An Unprecedented Class of Glycine-Derived Alkaloids. (monograph)
- G. Bringmann, J. Schlauer, H. Rischer, M. Wohlfarth, J. Mühlbacher, A. Buske, A. Porzel, J. Schmidt, G. Adam.
(2000). Revised Structure of Antidesmone, an Unusual Alkaloid from Tropical Antidesma Plants (Euphorbiaceae). (monograph)
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