Forschungsbericht

Third-party-funded project

Title:
Investigations on the Structure and Biosynthesis of Antidesmone from Antidesma membranaceum (Euphorbiaceae)

Project management at the University of Würzburg:

Prof. Dr. Gerhard Bringmann ,Tel: +49(0)931 888 5323,Fax: +49(0)931 888 4755,Mail: bringman@ chemie.uni-wuerzburg.de

Participating scientists:

Prof. Dr. Günther Adam , Institut für Pflanzenbiochemie (IPB Halle)
Dr. Reto Brun , Schweizerisches Tropeninstitut, Basel
Dr. Jan Schlauer
Dr. Heiko Rischer
Dr. Michael Wohlfarth

Abstract:
Feeding experiments with cell cultures revealed the structure of a novel glycine-derived acetogenic quinoline alkaloid from Antidesma membranaceum, which had originally been described as an isoquinoline alkaloid. Antidesmone is built up mainly from acetate units, the nitrogen-containing part, however, originates from glycine. Furthermore, antidesmone shows promising activities against Trypanosoma cruzi, which is the vector of Chagas disease.

Key words:
    Trypanosoma cruzi
    Chagas Disease
    Acetogenic Natural Products
    Glycine-Derived Quinoline Alkaloid
    Antidesmone
    Antidesma membranaceum

Projekt period: from 01.1999 to 12.2002

Funding institution:
Sonstige Stiftung ( Max-Buchner-Forschungsstiftung )

Publications:

G. Bringmann, J. Schlauer, H. Rischer, M. Wohlfarth, R. Haller, S. Bär, R. Brun. (2001). Antidesmone, a Novel Antitrypanosomal Alkaloid. (monograph)
G. Bringmann, H. Rischer, M. Wohlfarth, J. Schlauer. (2000). Biosynthesis of Antidesmone in Cell Cultures of Antidesma membranaceum (Euphorbiaceae): An Unprecedented Class of Glycine-Derived Alkaloids. (monograph)
G. Bringmann, J. Schlauer, H. Rischer, M. Wohlfarth, J. Mühlbacher, A. Buske, A. Porzel, J. Schmidt, G. Adam. (2000). Revised Structure of Antidesmone, an Unusual Alkaloid from Tropical Antidesma Plants (Euphorbiaceae). (monograph)

Links:
Research Group Prof. Bringmann - Homepage