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Third-party-funded project

Title:
Investigations on the Structure and Biosynthesis of Antidesmone from Antidesma membranaceum (Euphorbiaceae)

Project management at the University of Würzburg:

Participating scientists:

Abstract:
Feeding experiments with cell cultures revealed the structure of a novel glycine-derived acetogenic quinoline alkaloid from Antidesma membranaceum, which had originally been described as an isoquinoline alkaloid. Antidesmone is built up mainly from acetate units, the nitrogen-containing part, however, originates from glycine. Furthermore, antidesmone shows promising activities against Trypanosoma cruzi, which is the vector of Chagas disease.

Key words:
    Trypanosoma cruzi
    Chagas Disease
    Acetogenic Natural Products
    Glycine-Derived Quinoline Alkaloid
    Antidesmone
    Antidesma membranaceum

Projekt period: from 01.1999 to 12.2002

Funding institution:
Sonstige Stiftung ( Max-Buchner-Forschungsstiftung )

Publications:

Links:
Research Group Prof. Bringmann - Homepage