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Third-party-funded project

Title:
Preparation and in vivo evaluation of highly active antimalarial naphthylisoquinoline alkaloids

Project management at the University of Würzburg:

Participating scientists:

Abstract:
The urgent need for new antimalarial drugs is generally recognized, seen the worldwide spread of strains of malaria parasites (especially Plasmodium falciparum) resistent to chloroquine and to other clinically used drugs. Several representatives of the naphthylisoquinoline alkaloids and some other natural products have been found to display pronounced antiplasmodial activities against chloroquine-sensitive and -resistant P. falciparum strains in vitro, and against P. berghei in vivo, without any signs of toxicity. The goal of this project is the investigation of the preclinical antimalarial capacity of some selected alkaloids and related molecules, based upon structure-activity relationship analyses.

Key words:
    Plasmodium chabaudi chabaudi
    Tropical Medicinal Plants
    Structure-Activity Relationships
    Antimalarial Activity
    Bioassay-guided Search for Bioactive Compounds
    Naphthylisoquinoline Alkaloids
    Plasmodium falciparum

Projekt period: from 12.1999 to 12.2002

Funding institution:
Sonstige Stiftung ( World Health Organization, WHO, Genf ) ,Granting date: 18.11.1999

Preceding project:
Investigation of the Preclinical Antimalarial Potential of the Naphthylisoquinoline Alkaloids (WHO, ID No. 950 197)

Publications:

Links:
Research Group Prof. Bringmann - Homepage