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Third-party-funded project

Title:
"Low-Molecular Agents from Marine Organisms: Synthesis and Analytics" within the German Center of Excellence for "Marine Molecular Biotechnology", BIOTECmarin

Project management at the University of Würzburg:

Participating scientists:

Abstract:
Marine sponges, fungi and bacteria are known to produce a broad variety of biologically active secondary metabolites, a rich, but still untapped source of novel leads for the development of new pharmaceutics. Together with other scientist, we try to take advantage of this valuable potential of novel low-molecular natural products. Employing our LC triad consisting of the coupling techniques HPLC-NMR, HPLC-MS, and the HPLC-CD hyphenation in combination with quantum chemical CD calculations, we aim at a rapid and efficient metabolic profiling of crude extracts for new compounds, including the elucidation of their constitutions and relative and absolute configurations. Biological activities of extracts and isolated pure compounds are investigated by special test systems, i.a., for antitumor, antibacterial, or antiinflammatory properties. Pharmacologically active novel natural products constitute attractive goals for totalsynthesis.

Key words:
    Natural Products Total Synthesis
    LC Triad (HPLC-NMR-MS/MS-CD)
    Metabolic Profling
    antitumor activity
    Marine Bacteria
    Marine Fungi
    Marine Sponges
    Marine Organisms

Projekt period: from 01.2001 to 08.2004

Funding institution:
Sonstige öffentliche Mittel ( Universität Würzburg ) ,Granting date: 18.09.2001
Landeshaushalt Wissenschaftsministerium ( Bayerisches Staatsministerium für Wissenschaft, Forschung und Kunst )
Bund ( Bundesministerium für Bildung, Wissenschaft, Forschung und Technologie, BMBF )

Publications:

Links:
Research Group Prof. Bringmann - Homepage
Homepage BIOTECmarin