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Third-party-funded project

Title:
"Structural Elucidation and Chemical Modification of New Agents from Marine Organisms" within the Collaborative Research Project "Bioactive Natural Products from Marine Sponges and Associated Microorganisms (managed by the Zentaris AG)

Project management at the University of Würzburg:

Participating scientists:

Abstract:
Together with other scientists, we started to investigate the metabolic profile of marine sponges and associated microorganisms like fungi and bacteria applying our LC triad HPLC-NMR-MS/MS-CD. Besides isolation and structural elucidation of the full 3-dimensional structure of novel bioactive secondary metabolites, we also used modern, 'non-invasive' NMR imaging methods to monitor an 'NMR image' of the interior of a living sponge, based on the water distribution in the ensemble of the object. The 'picture' taken non-destructively shows the sponge inhabited (and thus 'mobilized') by a hermit-crab with its snail-shell.

Key words:
    In Vivo NMR Imaging
    Bioassay-guided Search for Potent Agents
    Bioactive Secondary Metabolites
    Marine Sponges

Projekt period: from 1.1999 to 12.2001

Funding institution:
Wirtschaftsunternehmen ( Zentaris AG, vormals ASTA Medica ) ,Granting date: 17.12.1998
Bund ( Bundesministerium für Bildung, Wissenschaft, Forschung und Technologie, BMBF )

Publications:

Links:
Research Group Prof. Bringmann - Homepage