Third-party-funded project
Title:
"Structural Elucidation and Chemical Modification of New Agents from Marine Organisms" within the Collaborative Research Project "Bioactive Natural Products from Marine Sponges and Associated Microorganisms (managed by the Zentaris AG)
Project management at the University of Würzburg:
Participating scientists:
- Dr. Eckhard Günther
, Zentaris AG (vormals ASTA Medica)
- Prof. Dr. Axel Haase
, Physikalisches Institut der Universität Würzburg, Lehrstuhl für Experimentelle Physik V
- Dr. Karsten Schaumann
, Alfred-Wegener-Institut für Polar- und Meeresforschung, Bremerhaven
- Prof. Dr. J.F. Imhoff
, Institut für Meereskunde der Universität Kiel
- Prof. Dr. Peter Proksch
, Institut für Pharmazeutische Biologie der Universität Düsseldorf
- Prof. Dr. W.E.G. Müller
, Institut für Physiologische Chemie der Universität Mainz
- Lebensmittelchemiker Gerhard Lang
,Tel: +49(0)931 888 5324,Mail: lang@chemie.uni-wuerzburg.de
- Dr. Michael Wohlfarth
- Dr. Markus Heubes
Abstract:
Together with other scientists, we started to investigate the metabolic profile of marine sponges and associated microorganisms like fungi and bacteria applying our LC triad HPLC-NMR-MS/MS-CD. Besides isolation and structural elucidation of the full 3-dimensional structure of novel bioactive secondary metabolites, we also used modern, 'non-invasive' NMR imaging methods to monitor an 'NMR image' of the interior of a living sponge, based on the water distribution in the ensemble of the object. The 'picture' taken non-destructively shows the sponge inhabited (and thus 'mobilized') by a hermit-crab with its snail-shell.
Key words:
In Vivo NMR Imaging
Bioassay-guided Search for Potent Agents
Bioactive Secondary Metabolites
Marine Sponges
Projekt period:
from 1.1999 to 12.2001
Funding institution:
Wirtschaftsunternehmen ( Zentaris AG, vormals ASTA Medica ) ,Granting date: 17.12.1998
Bund ( Bundesministerium für Bildung, Wissenschaft, Forschung und Technologie, BMBF )
Publications:
- R.A. Edrada, M. Heubes, G. Brauers, V. Wray, A. Berg, U. Gräfe, M. Wohlfarth, J. Mühlbacher, K. Schaumann, Sudarsono, G. Bringmann, P. Proksch.
(2002). Online Analysis of Xestodecalactones A-C, Novel Bioactive Metabolites from the Fungus Penicillium cf. montanense and Their Subsequent Isolation from the Sponge Xestospongia exigua. (monograph)
- G. Brauers, R.A. Edrada, R. Ebel, P. Proksch, V. Wray, A. Berg, U. Gräfe, C. Schächtele, F. Totzke, G. Finkenzeller, D. Marme, J. Kraus, M. Münchbach, M. Michel, G. Bringmann, K. Schaumann.
(2000). Anthraquinones and Betaenone Derivatives from the Sponge-Associated Fungus Microsphaeropsis Species: Novel Inhibitors of Protein Kinases. (monograph)
- G. Bringmann, K. Wolf, T. Lanz, A. Haase, J. Hiort, P. Proksch, W.E.G. Müller.
(1999). Direct demonstration of spatial water distribution in the sponge Suberites domuncula by in vivo NMR imaging. Mar. Ecol. Progr. Ser. 189: 307-310, (scientific article)
- C. Eder, P. Proksch, V. Wray, K. Steube, G. Bringmann, R.W.M. van Soest, Sudarsono, E. Ferdinandus, L.A. Pattisina, S. Wiryowidagdo, W. Moka.
(1999). New Alkaloids from the Indopacific Sponge Stylissa carteri. J. Nat. Prod. 62: 184-187, (scientific article)
Links:
Research Group Prof. Bringmann - Homepage
