Third-party-funded project
Title:
"New Agents from Tropical Plants and Soil Organisms: Isolation, Structure Elucidation, and Chemical Modification" within the Collaborative Research Project entitled "Molecular Interaction between Targets and Natural Products as a Tool for the Identification of New Agents and Agent Models for Agrochemical and Pharmaceutical Research" (managed by the BASF AG)
Project management at the University of Würzburg:
Participating scientists:
Abstract:
Tropical medicinal plants produce a variety of biologically active secondary metabolites, a rich, but still largely untapped source of novel leads for the development of new agrochemicals and pharmaceutics. After selection of plants by ethnobotanical criteria, biological activities of plant extracts and isolated compounds were investigated by special molecular test systems (established by the BASF AG). Selected fields of indication are herbicidal, fungicidal, anti-tumor, CNS, and anti-hypertensive activities. According to these criteria, crude plant extracts of different polarity will be tested to identify the active principle.
Key words:
Ancistrocladaceae and Dioncophyllaceae
Pharmaceuticals
Agrochemicals
Novel Leads
Bioassay-guided Search for New Agents
Tropical Medicinal Plants
Dioncophylline
Projekt period:
from 11.1997 to 10.2000
Funding institution:
Bund ( Bundesministerium für Bildung, Wissenschaft, Forschung und Technologie , BMBF ) ,Granting date: 28.11.1997
Wirtschaftsunternehmen ( BASF AG )
Preceding project:
BASF/BMBF-Verbundprojekt (1994 -1997), Förderkennzeichen: 0310722
Publications:
- R. Feling, K Polborn, W. Steglich, J. Mühlbacher, G. Bringmann.
(2001). The Absolute Configuration of the Mushroom Metabolites Involutin and Chamonixin. Tetrahedron 57: 7857-7863, (scientific article)
- G. Bringmann, A. Hamm, J. Kraus, M. Ochse, N. Noureldeen, D.N. Jumbam.
(2001). Gardenamide A from Rothmannia urcelliformis (Rubiaceae) - Isolation, Absolute Stereostructure, and Biomimetic Synthesis from Genipine. Eur. J. Org. Chem., 1983-1987, (scientific article)
- G. Bringmann, C. Günther, E.-M. Peters.
(2001). First Total Synthesis of the 7,6-Coupled Antifungal Naphthylisoquinoline Alkaloid Dioncophylline B. Tetrahedron 57: 1253-1259, (scientific article)
- G. Bringmann, K. Messer, W. Saeb, E.-M. Peters.
(2001). The absolute configuration of (+)-Isoshinanolone and in situ LC-CD Analysis of its Stereoisomers from Crude Extracts. Phytochemistry 56: 387-391, (scientific article)
- G. Bringmann, S. Tasler.
(2001). Oxidative Aryl Coupling Reactions: A Biomimetic Approach to Configurationally Unstable or Axially Chiral Biaryl Natural Products and Related Bioactive Compounds. Tetrahedron 57: 331-343, (scientific article)
- G. Bringmann, W. Saeb, J. Mies, K. Messer, M. Wohlfarth, R. Brun.
(2000). One-Step Oxidative Dimerization of Genuine, Unprotected Naphthylisoquinoline Alkaloids to Give Michellamines and Other Bioactive Quateraryls. Synthesis, 1843-1847, (scientific article)
- G. Bringmann, W. Saeb, M. Wohlfarth, K. Messer, R. Brun.
(2000). Jozipeltine A, a Novel, Unnatural Dimer of the Highly Hydroxylated Naphthylisoquinoline Alkaloid Dioncopeltine A. Tetrahedron 56: 5871-5875, (scientific article)
- G. Bringmann, A. Hamm, C. Günther, M. Michel, R. Brun, V. Mudogo.
(2000). Ancistroealaines A and B, Two New Bioactive Naphthylisoquinolines, and Related Naphthoic Acids from Ancistrocladus ealaensis. J. Nat. Prod. 63: 1465-1470, (scientific article)
- G. Bringmann, C. Günther, W. Saeb, J. Mies, A. Wickramasinghe, V. Mudogo, R. Brun.
(2000). Ancistrolikokines A-C: New 5,8'-Coupled Naphthylisoquinoline Alkaloids from Ancistrocladus likoko. J. Nat. Prod. 63: 1333-1337, (scientific article)
- G. Bringmann, J. Kraus, U. Schmitt, C. Puder, A. Zeeck.
(2000). Determination of the Absolute Configurations of gamma-Rubromycin and Related Spiro Compounds by Quantum Chemical CD Calculations. Eur. J. Org. Chem., 2729-2734, (scientific article)
- G. Bringmann, C. Günther, W. Saeb, J. Mies, R. Brun, L. Ake Assi.
(2000). 8-O-Methyldioncophyllinol B and Revised Structures of other 7,6'-Coupled Naphthylisoquinoline Alkaloids from Triphyophyllum peltatum (Dioncophyllaceae). Phytochemistry 54: 337-346, (scientific article)
- G. Bringmann, M. Ochse, G. Zotz, K. Peters, E.-M. Peters, R. Brun, J. Schlauer.
(2000). 6-Hydroxyluteolin-7-O-(1''-alpha-rhamnoside) from Vrisea sanguinolenta Cogn. and Marchal (Bromeliaceae). Phytochemistry 53: 965-969, (scientific article)
- G. Bringmann, M. Ochse, M. Michel.
(2000). Gentrymine B, an N-Quaternary Ancistrocladus Alkaloid: Stereoanalysis, Synthesis, and Biomimetic Formation from Gentrymine A. Tetrahedron 56: 581-585, (scientific article)
- G. Bringmann, T. Ortmann, D. Feineis, E.-M. Peters, K. Peters.
(2000). A New Central Binaphthalene Building Block for Michellamine Syntheses. Synthesis, 383-388, (scientific article)
- G. Bringmann, C. Günther, J. Mühlbacher, M.D. Lalith, P. Gunathilake, A. Wickramasinghe.
(2000). Tropane Alkaloids from Erythroxylum zeylanicum O.E. Schulz (Erythroxylaceae). Phytochemistry 53: 409-416, (scientific article)
- G. Bringmann, J. Holenz, W. Saeb, L. Aké Assi, K. Hostettmann.
(1999). Dioncophylline A as a Larvicide against Aedes aegypti. Pharm. Pharmacol. Lett. 9: 24-25, (scientific article)
- G. Bringmann, D. Herzberg, G. Adam, F. Balkenhohl, J. Paust.
(1999). A Short and Productive Synthesis of (R)-alpha-Lipoic Acid. Z. Naturforsch. 54b: 655-661, (scientific article)
- A. Maier, J. Müller, P. Schneider, H.-P. Fiedler, I. Groth, F.S.K. Tayman, F. Teltschik, C. Günther, G. Bringmann.
(1999). (2E,4Z)-Decadienoic Acid and (2E,4Z,7Z)-Decatrienoic Acid, Two Herbicidal Metabolites from Streptomyces viridochromogenes Tü6105. Pestic. Sci. 55: 733-739, (scientific article)
- G. Bringmann, F. Teltschik, M. Michel, S. Busemann, M. Rückert, R. Haller, S. Bär, S.A. Robertson, R. Kaminsky.
(1999). Ancistrobertsonines B, C, and D as well as 1,2-didehydroancistrobertsonine D from Ancistrocladus robertsoniorum. Phytochemistry 52: 321-332, (scientific article)
- G. Bringmann, K. Messer, M. Wohlfarth, J. Kraus, K. Dumbuya, M. Rückert.
(1999). HPLC-CD On-Line Coupling in Combination with HPLC-NMR and HPLC-MS/MS for the Determination of the Full Absolute Stereostructure of New Metabolites in Plant Extracts. Anal. Chem. 71: 2678-2686, (scientific article)
- G. Bringmann, M. Ochse, K. Wolf, J. Kraus, K. Peters, E.-M. Peters, M. Herderich, L. Aké Assi, F.S.K. Tayman.
(1999). 4-Oxonicotinamide-1-(1'-beta-D-ribofuranoside) from Rothmannia longiflora Salisb. (Rubiaceae). Phytochemistry 51: 271-276, (scientific article)
- G. Bringmann, M. Rückert, K. Messer, O. Schupp, A.M. Louis.
(1999). Use of on-line High-Performance Liquid Chromatography - Nuclear Magnetic Resonance Spectrometry Coupling in Phytochemical Screening Studies: Rapid Identification of Metabolites in Dioncophyllum thollonii. J. Chromatogr. A 837: 267-272, (scientific article)
- G. Bringmann, M. Rückert, W. Saeb, V. Mudogo.
(1999). Characterization of Metabolites in Plant Extracts of Ancistrocladus likoko by High-Performance Liquid Chromatography Coupled on-line with 1H NMR Spectroscopy. Magn. Reson. Chem. 37: 98-102, (scientific article)
- S.E. Drewes, M.M. Horn, O.Q. Munro, N. Ramesar, M. Ochse, G. Bringmann, K. Peters, E.-M. Peters.
(1999). Stereostructure, Conformation and Reactivity of beta- and alpha-gardiol from Burchellia bubalina. Phytochemistry 50: 387-394, (scientific article)
- G. Bringmann, C. Günther.
(1999). First Total Synthesis of Dioncophylline B, a 7,6'-Coupled Naphthylisoquinoline Alkaloid. Synlett, 216-218, (scientific article)
- G. Bringmann, W. Saeb, M. Rübenacker.
(1999). Directed Joint Total Synthesis of the Three Naphthylisoquinoline Alkaloids Dioncolactone A, Dioncopeltine A, and 5'-O-Demethyldioncopyhlline A. Tetrahedron. 55: 423-432, (scientific article)
- G. Bringmann, M. Wenzel, T.R. Kelly, M.R. Boyd, R.J. Gulakowski, R. Kaminsky.
(1999). Octadehydromichellamine, a Structural Analog of the Anti-HIV Michellamines without Centrochirality. Tetrahedron 55: 1079-1086, (scientific article)
Links:
Research Group Prof. Bringmann - Homepage
