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Third-party-funded project

Title:
"Metal-induced Synthesis and Utilization of Axially Chiral Biaryls" within the Center Grant (Sonderforschungsbereich 347) "Selective Reactions of Metal-Activated Molecules"

Project management at the University of Würzburg:

Participating scientists:

Abstract:
Axially chiral biaryl compounds are of increasing importance as auxiliaries in asymmetric synthesis and as pharmacologically active natural products, and thus constitute attractive synthetic goals. We have detected a new principle for the directed construction of stereochemically homogeneous biaryl systems, by atropisomer-selective cleavage of configuratively unstable lactone-bridged biaryls using metal-activated chiral O-, N-, or H-nucleophiles to give biaryls with high stereocontrol.

Key words:
    Naphthylisoquinoline Alkaloids
    Knipholone-Type 1-Phenylanthraquinones
    Dimeric Carbazole Alkaloids
    Lactone Concept
    Lactone-Bridged Biaryls
    Stereoselective Biaryl Synthesis
    Axially Chiral Biaryls
    Mastigophorenes

Projekt period: from 01.1999 to 12.2001

Funding institution:
DFG ( Sonderforschungsbereich 347, vierte Förderperiode ) ,Granting date: 19.06.1998

Preceding project:
SFB 347, dritte Förderperiode

Publications:

Links:
Research Group Prof. Bringmann - Homepage