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Third-party-funded project

Title:
Genotoxicity of Dioxetanes and Photo-Fenton Reagents

Project management at the University of Würzburg:

Participating scientists:

Abstract:
The chemical, analytical, mechanistic, and biochemical investigations of oxidative DNA damage caused by electronically excited species and oxyl radicals are the main objectives of this multidisciplinary research project in the field of photobiology. The necessary electronically excited species, in particular carbonyl compounds, are generated by direct irradiation of respective ketones or by thermal decomposition of dioxetanes, while oxyl radicals are produced photochemically from photo-Fenton reagents.

Key words:
    Photobiology
    Genotoxicity
    Cytotoxicity
    Mutagenicity
    DNA Photooxidation
    DNA Strand Break
    Dioxetane
    Electronically Excited Species
    Oxyl Radical
    Photo-Fenton Reagent

Projekt period: from 01.1997 to 12.1999

Funding institution:
DFG ,Granting date: 19.12.1996

Preceding project:
SFB 172 vierte Projektperiode

Publications:

Links:
Additional Publication