Lehrstuhl für Organische Chemie II
Am Hubland, 97074 Würzburg
Other participating persons and organisations:
Research foci (and basic equipment-based research projects):
Metal- and Enzyme-Catalyzed Stereoselective Reactions:
In this research area, we deal with metal- and enzyme-catalyzed selective oxidations. The primary objective is the development of efficient and environmentally benign methods for chemo-, regio-, diastereo- and enantioselective preparation of synthetically valuable and industrially relevant oxyfunctionalized products by metal complexes and enzymes as well as microorganisms. For the selective oxyfunctionalizations through metal catalysis are used oxo complexes of Mn, Fe, and Cr, peroxo complexes of Re, Mo and W, and peroxy complexes of Ti and V. As oxygen donors are applied principally hydrogen peroxide and its derivatives. In biotransformations, preferentially metalloenzymes are employed as catalysts, in particular peroxidases and oxidases . Additionally, microorganisms (soil bacteria and fungi) with peroxidase or oxidase activity are used directly for biocatalytic transformations, instead of isolated enzymes.
For the results in this research area, consult the above-mentioned publications.
Rewards and prizes:
Frau C. Mock-Knoblauch: DAAD Fellowship for a research stay in Japan, 1997; Faculty Award (Dissertation) of the Faculty of Chemistry and Pharmacy, 2000.
Herr Z. Lukacs: Faculty Award (Dissertation) of the Faculty of Chemistry and Pharmacy, 2000.
Dr. S. Hajra: Alexander-von-Humboldt Fellowship, 1999-2000.
Dr. P. Bheema Rao: Alexander-von-Humboldt Fellowship, 1999-2000.
Dr. O. Weichold: Lynen Fellowship, 2001.
Dr. R. Zhang: Alexander-von-Humboldt Fellowship, 2001-2002.
HPLC, Chiralyser, GC, MS, NMR Spectrometers (600, 400, 250 and 200 MHz), Polarimeter.