Forschungsschwerpunkt: |
C 3-Prof. f. Pharm. Chemie (Högger)
Am Hubland, 97074 Würzburg Mail: p.hoegger@pharmazie.uni-wuerzburg.de Url: http://www.pharmazie.uni-wuerzburg.de/PharmChem/AKHoegger/index.html |
Wissenschaftliche Mitglieder:
Professoren:
Wissenschaftliche Mitarbeiter:
Forschungsschwerpunkte (und Projekte auf Basis der Grundausstattung):
Regulation, biochemische und klinische Effekte des antiinflammatorischen Proteins CD163
Ergebnisse:
Högger P, Erpenstein U, Rohdewald P, Sorg C.
Biochemical characterization of a glucocorticoid-induced membrane protein (RM 3/1) on human monocytes and ist application as model system for ranking glucocorticoid potency.
Pharm Res 1998; 15:296-302
Högger P, Dreier J, Droste A, Buck F, Sorg C.
Identification of the integral membrane protein RM3/1 on human monocytes as a glucocorticoid-inducible member of the scavenger receptor cysteine-rich family (CD163).
J Immunol 1998; 161:1883-1890
Droste A, Sorg C, Högger P.
Shedding of CD163, a novel regulatory mechanism for a member of the scavenger receptor cysteine-rich family.
Biochem Biophys Res Commun 1999; 256:110-113
Van den Heuvel MM, Tensen CP, van As JA, Van den Berg TK, Fluitsma DM, Dijkstra CD, Döpp EA, Droste A, Van Galen FA, Högger P, Beelen RHJ.
Regulation of the expression of the cysteine-rich scavenger receptor CD163 on human macrophages: cross-linking of CD163 induces signalling and activation.
J Leukoc Biol 1999; 66:858-866
Sulahian TH, Högger P, Wardwell K, Goulding NJ, Sorg C, Droste A, Stehling M, Guyre PM.
Human monocytes express CD163 which is upregulated by IL-10 and identical to p155.
Cytokine 2000; 12:1312-1321
Högger P, Sorg C.
Soluble CD163 inhibits phorbol ester-induced lymphocyte proliferation.
Biochem Biophys Res Commun 2001; 288:841-843
Matsushita N, Kashiwagi M, Wait R, Nagayoshi R, Nakamura M, Matsuda T, Högger P, Guyre PM, Nagase H, Matsuyama T.
Elevated levels of soluble CD163 in sera and fluids from rheumatoid arthritis patients and inhibition of the shedding of CD163 by TIMP-3.
Clin Exp Immunol 2002; 130:156-161
Ausstattung:
Zellkultureinrichtung
ELISA-Reader und Washer
Tiefkühlschrank (-80 °C)
PCR-Cycler