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Third-party-funded project

Contribution of Ca2+-permeable AMPA/KA receptors to glutamate-induced Ca2+rise in embryonic lumbar motoneurons in situ

Project management at the University of Würzburg:

Participating scientists:

Receptors of the AMPA/KA-family modulate dendrite growth in cultured neurons. We could show, that embryonic motoneurons in tissue-specific slice cultures exhibit Ca influx after activation of AMPA receptors, and that by this way dendrite growth synaptogenesis is regulated during a critical phase of embryonic development between embryonic day 13 and postnatal day 2.

Key words:
    Motoneuron disease
    Spinal cord

Projekt period: from 01.1999 to 12.2000

Funding institution:
DFG ( Schwerpunktprogramm "Molekulare Physiologie der Synapsen" ) ,Granting date: 19.05.1999

Preceding project:
842 0689 DFG Se 697/2-1


Institute for Clinical Neurobiology