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Third-party-funded project

A trial of recombinant methionyl human brain derived neurotrophic factor administered by intrathecal infusion to patients with amyotrophic lateral sclerosis

Project management at the University of Würzburg:

Participating scientists:

BDNF is a potent survival factor for lesioned and degenerating motoneurons in the various animal models for human disease. We could show in a first phase 1/2 clinical study that intrathecal infusion of BDNF is well tolerated, and that BDNF is taken up by degenerating motoneurons and activates signalling pathways in these cells.

Key words:
    Clinical trial
    Brain-derived neurotrophic factor
    Amyotrophic lateral sclerosis

Projekt period: from 01.1999 to 12.2000

Funding institution:
DFG ( To 61/8-3 ) ,Granting date: 19.08.1996
Wirtschaftsunternehmen ( Amgen )

Preceding project:
8420135 DFG To 61/8-1


Institute for Clinical Neurobiology