Does the survival motor neuron protein (SMN) interact with bcl-2?
Project management at the University of Würzburg:
Previous reports have suggested that the protein which is defective in Spinal Muscular Atrophy, the survival of motoneuron gene product, interacts with bcl-2. Results from our research group have indicated that deficiency of bcl-2 leads to postnatal degeneration of motoneurons. We have investigated subcellular distribution of the smn-protein and compared it to bcl-2 in various animal models. However, these data did not provide proof for functional interaction of bcl-2 and smn. They rather indicated that the primary effect underlying Spinal Muscular Atrophy does not modulate neuronal survival by axonal growth, and by this means significantly differ from animal models in which the bcl-2 gene is inactivated.
Projekt period: from 01.1999 to 12.2000
DFG ( To 61/8-3 und 61/8-4 ) ,Granting date: 07.07.1997
DFG To 61/-1