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Third-party-funded project

Title:
Function and biological relevance of Selenoprotein P for the metabolism of Selenium and tumor development in the transgenic mouse

Project management at the University of Würzburg:

Participating scientists:

Abstract:
Selenium exerts its biological function mainly as selenocysteine, the 21st proteinogenic amino acid, which is found in the active site of 30-50 proteins and enzymes.
Epidemiological, interventional and prevention data suggest a link between low selenium supply and cancer.
Selenoprotein P, a plasma protein mainly secreted by the liver, contains up to 50 % of selenium in plasma.
This project will analyze the role of selenoprotein P in the context of tumorigenesis in mouse models.

Key words:
    selenoprotein
    tumor
    cancer
    selenium

Projekt period: from 09.2001 to 08.2005

Funding institution:
Sonstige Stiftung ( Dt. Krebshilfe - Dr. Mildred Scheel Stiftung )

Publications: