Function and biological relevance of Selenoprotein P for the metabolism of Selenium and tumor development in the transgenic mouse
Project management at the University of Würzburg:
Selenium exerts its biological function mainly as selenocysteine, the 21st proteinogenic amino acid, which is found in the active site of 30-50 proteins and enzymes.
Epidemiological, interventional and prevention data suggest a link between low selenium supply and cancer.
Selenoprotein P, a plasma protein mainly secreted by the liver, contains up to 50 % of selenium in plasma.
This project will analyze the role of selenoprotein P in the context of tumorigenesis in mouse models.
Projekt period: from 09.2001 to 08.2005
Sonstige Stiftung ( Dt. Krebshilfe - Dr. Mildred Scheel Stiftung )