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Research focus:  

Klinische Forschergruppe Zelldifferenzierung und lokale Regulationsysteme
Röntgenring 11, 97070 Würzburg
Mail: kfg.zell@mail.uni-wuerzburg.de
Url: http://www.uni-wuerzburg.de/zelldifferenzierung/index.html

Scientific members:

   Professors:

   Outside lecturer:

   Scientific assistants:

Research foci (and basic equipment-based research projects):
see websites
http://www.uni-wuerzburg.de/zelldifferenzierung/index.html
http://www.uni-wuerzburg.de/spp-selen
http://www.charite.de/expendo
http://www.uni-wuerzburg.de/GK639/
http://www.uni-wuerzburg.de/izkf/

Results:
see websites
http://www.uni-wuerzburg.de/zelldifferenzierung/index.html
http://www.uni-wuerzburg.de/spp-selen
http://www.charite.de/expendo
http://www.uni-wuerzburg.de/GK639/
http://www.uni-wuerzburg.de/izkf/

See final report Clinical Reserch Group ?Cell Differentiation and Local Regulatory Systems?, available via Frau S. Brauner, Med. Poliklinik, Abt. Molekulare Innere Medizin, Röntgenring 11, 97070 Würzburg, Germany

Publikations:
60. Baur A, Köhrle J 1999 Type I 5'-deiodinase is stimulated by iodothyronines and involved in thyroid hormone metabolism in human somatomammotroph GX cells. Eur J. Endocrin. 140:367-370 61. Hoang-Vu C, Bull K, Schwarz I, Krause G, Schmutzler C, Aust G, Köhrle J, Dralle H. 1999 Regulation of CD97 protein in thyroid carcinoma. J Clin. Endocrin. Metab. 84:1104-1109 62. Hoang-Vu C, Bull K, Schwarz I, Holtz J, Schmutzler C, Köhrle J, Dralle H. 1999 Expression of ?death-domain?-receptors and their ligands in benign goitre and thyroid carcinoma. Langenbeck?s Arch. Chir. Suppl. I (Forumband 1999) 197-200 63. Bähr K, Dreher I, Köhrle J 1999 Selenium supplementation by selenium yeast and sodium selenite. analysis of selenium state as well as risks of deficiency and intoxication. Laboratory Medicine 23:594-599 64. Schütze N, Fritsche J, Ebert R, Schneider D, Köhrle J, Andreesen R, Kreutz M, Jakob F 1999 The selenoprotein thioredoxin reductase is expressed in blood monocytes and THP1 human myeloid leukemia cells ? Regulation by 1,25?Dihydroxyvitamin D3 and selenite. Biofactors 10:329-338. 65. Körber C, Schmutzler C, Rendl J, Köhrle, J, Griesser H, Simon D, Reiners C 1999 Increased I-131 uptake in local recurrrence and distant metastases after second treatment with retinoic acid. Clin Nucl Med 24:849-851 66. Mostert V, Dreher I, Köhrle J, Abel J 1999 Transforming growth factor-b1 inhibits expression of selenoprotein P in cultured human liver cells FEBS Letters 460:23-26 67. Hesse-Bähr K, Köhrle J 2000 The influence of the cytokines Il?1β and IFNg on the expression of selenoproteins in the human hepatocarcinoma cell line HepG2. Biofactors 11:83-85 68. Mörk H, Al-Taie OH, Bähr K, Zierer A, Beck K, Scheurlen M, Jakob F, Köhrle J 2000 Inverse mRNA expression of the selenocysteine-containing proteins GI-GPx and SeP in colorectal adenomas compared to adjacent normal mucosa. Nutr. & Cancer 37:108-116 69. Baur A, Bauer K, Jarry H Köhrle J 2000 Effects of proinflammatory cytokines on anterior pituitary 5'-deiodinase type I and type II J. Endocrinology 167: 505-515 70.Mostert V, Wolff S, Dreher I, Köhrle J, Abel J (2001) Identification of a transforming-growth-factor-β-responsive element within the promoter of human selenoprotein P Eur. J. Biochem 268:6176-6181 71. Jakobs TC, Mentrup B, Schmutzler C, Dreher C, Glaser F, Köhrle J 2002 Proinflammatory cytokines inhibit the expression and function of type I 5'?deiodinase in HepG2 hepatocarcinoma cells Eur. J. Endo 146:559-566 72. Brtko J, Bobadova J, Podoba J, Schmutzler C, Köhrle J 2002 Functional thyroid hormone receptors and the type I iodothyronine 5'-deiodinase activity of human toxic adenomas and benign cold nodules Exp. Clin Endo & Diabetes 110:166-170 73. Schmutzler C, Schmitt TL, Glaser F, Köhrle J, Loos U 2002 The promoter of the human sodium/iodide-symporter gene responds to retinoic acid Mol. Cell. Endo. 189:145-155 74. Hoang-Vu C, Boltze C, Poremba C, Dockhorn-Dworniczak B, Köhrle J, Schmutzler C, Rath FW, Dralle H (2002) Expression and regulation of telomerase genes in thyroid carcinoma Int J Oncol 21:265-272 75. Al-Taie O, Seufert J, Mörk H, Treis H, Mentrup B, Thalheimer A, Starostik P, Abel J, Scheurlen M, Köhrle J, Jakob F (2002) A complex repeat structure of the selenoprotein P promoter contains a functionally relevant polymorphism and is unstable under conditions of mismatch repair deficiency Eur. J Hum Genetics 10:499-504 76. Baur A, Buchfelder M, Köhrle J (2002) Expression of 5?-deiodinase enzymes in normal pituitaries and various human pituitary adenomas. Eur. J. Endo. 147:263-268 77. Simon D, Körber C, Krausch M, Segering J, Groth P, Görges, Grünwald, Müller-Gärtner, Schmutzler C, Köhrle J, Röher HD, Reiners C (2002) Clinical impact of retinoids in redifferentiation therapy of advanced Thyroid cancer ? final results of a Pilot study. Eur. J. Nucl. Med. Mol. Imaging 29:775-782 Reviews and Book Chapters 69. Schmutzler C, Winzer R, Rendl J, Reiner C, Köhrle J 1999 Reverse transcriptase polymerase chain reaction from fine needle aspiration biopsies: A potential new diagnostic tool for thyroid gland disorders. Int. Seminar ?Radiation and Thyroid Cancer?, Cambridge, UK, 20-23 July 1998, Eds. G. Thomas, A. Karaoglou, E.D. Williams, World Scientific Publishing, Inc., London, 1999, pp.469-476 70. Köhrle J 1999 The trace element selenium and the thyroid gland. Biochimie 81:527-533 (peer reviewed) 71. Baur A, Köhrle J: Lokale Schilddrüsenhormonaktivierung in Zielzellen, der letzte Schritt der Schilddrüsenhormonsynthese, in Innere Medizin zwischen Grundlagenforschung und Klinik. Jakob F and Wilhelm M. Bühl, Baden, Konkordia Verlag GmbH, 1999:pp. 53-58. 72. Schmutzler C, Köhrle J: Hormonelle Redifferenzierung von Schilddrüsenkarzinomen durch Retinoide ? eine Brücke zwischen Endokrinologie, Onkologie und Nuklearmedizin, in Innere Medizin zwischen Grundlagenforschung und Klinik. Jakob F and Wilhelm M. Bühl, Baden, Konkordia Verlag, GmbH, 1999:pp. 59-62. 73. Dreher I, Hesse K, Schütze N, Mörk H, Al-Taie O, Jakob F, Köhrle J: Menschliche Selenoproteine in der Endokrinologie und Onkologie ? Endpunkte der biologischen Effekte des essentiellen Spurenelements Selen, in Innere Medizin zwischen Grundlagenforschung und Klinik. Jakob F and Wilhelm M. Bühl, Baden, Konkordia Verlag GmbH, 1999:pp. 63?67. 74. Jakob F, Köhrle J 1999 Selen in Ernährung, Prävention und Therapie ? Eine Bestandsaufnahme. Internist 75. Köhrle J 1999 Local activation and inactivation of thyroid hormones: the deiodinase family. Mol Cell Endocrinol 151:103?119. 76. Köhrle J 1999 Der Natrium?Iodid?Symporter NIS: Funktion, Regulation und klinische Relevanz. Z ärztl Fortbild Qual.sich 93:17?22. 77. Köhrle J 1999 Selen in der Onkologie: Ein essentielles Spurenelement auf dem Prüfstand. In/Fo/Onkologie 2:1 (Editorial) 78. Mörk H, Al?Taie O, Dreher I, Karvar S, Scheurlen M, Köhrle J, Jakob F 1999 Expression von Selenoproteinen im Gastrointestinaltrakt ? Implikationen für die Karzinogenese. In/Fo/Onkologie 2:12?20. 79. Ebert-Dümig R, Seufert J, Schneider D, Köhrle J, Schütze N, Jakob F. 1999 Expression von Selenoproteinen in Monozyten - Implikationen für das Immunsystem. Med Klinik 94, Suppl. III:29-34 80. Köhrle J 2000 The deiodinase family - Selenoenzymes regulating thyroid hormone availability and action. Cellular and Molecular Life Sciences 57:1853-1863 81. Köhrle J 2000 The selenoenzyme family of deiodinase isozymes controls local thyroid hormone availability. Rev. Endocrin. Metab. Disease 1:49-58 82. Köhrle J 2000 Thyroid hormone metabolism and action in the brain and pituitary. Acta Med Austriaca 27:1-7 83. Schmutzler C, Köhrle J 2000 Innovative strategies for the treatment of thyroid cancer. Eur J Endocrin 143:15-24 84. Köhrle J 2000 Wirkungsmechanismen der Schilddrüsenhormone. In: Schilddrüse 1999 edited by Seibel MJ, Weinheimer B and Ziegler R., Berlin, W. de Gruyter, pp. 1-25 85. Schmutzler C, Köhrle J 2000 Retinoid acid redifferentiation therapy for thyroid cancer. Thyroid 10:393-406 86. Leonard JL, Köhrle J 2000 Intracellular pathways of iodothyronine metabolism. In: Werner and Ingbar's 'The Thyroid', 8th ed., edited by Braverman LE, Utiger RD, Philadelphia: J.B. Lippincott, pp. 136-173. 87. Köhrle J, Schmutzler C, Schütze N, Jakob F 2000 Angiogenesis and vascular remodelling in the human thyroid. In: The Vascular System in Thyroid Disease, eds.: P. Nawroth, M. Seibel, R. Ziegler. Berliner Medizinische Verlagsanstalt, Berlin, pp. 29-39 88. Köhrle J, Brigelius-Flohé R, Böck A, Gärtner R, Meyer O, Flohé L 2000 Selenium in Biology: Facts and Medical Perspectives Biol Chem 381:849-864 89. Köhrle J 2000 Flavonoids as risk factor for goiter and hypothyroidism. In: The Thyroid and Environment, eds.: F. Petér, W. Wiersinga, U. Hostalek, Schattauer, Stuttgart-New York, 41-63 90. Köhrle J 2002 Iododthyronine Deiodinases. In: Methods in Enzymology, Vol. 347, Academic Press, New York, pp. 125-167 91. Köhrle J 2002 Selenoproteins in: Wiley Encyclopedia of Molecular Medicine, J. Wiley & Sons Inc, NY. pp. 2880-2881 92. Köhrle J (2002) Iod. Kap. 22, In: Biesalski HK, Köhrle J, Schümann K, eds. 2002 Vitamine, Spurenelemente, Mineralstoffe. Thieme Verlag Stuttgart, pp. 172-182 93. Köhrle J (2002) Selen, Kap. 21, In: Biesalski HK, Köhrle J, Schümann K, eds. 2002 Vitamine, Spurenelemente, Mineralstoffe. Thieme Verlag Stuttgart, pp, 161-172 94. Köhrle J (2002) Coenzyme, Prosthetische Gruppen und Vitamine. In: Schartl, Schmitt, Unsicker 2002 Lehrbuch Vorklinik, Ärzte Verlag, Heidelberg, (in press) 95. Köhrle J, Jakob F, Contempré B, Dumont JE (2002) Selenium, the Thyroid, and the Endocrine System. Endocrine Reviews (invited review, in revision). 96. Köhrle J, Schmutzler C (2002) Iodstoffwechsel, Schilddrüsenhormonsynthese und -sekretion, in: Die Schilddrüse: Grundlagen - Diagnostik und Therapie von Schilddrüsenerkrankungen, Eds. Gärtner R, Mann K. Wiss. Verlagsges. Stuttgart, Kap. 2 (in press)

Links:
website Clinical Research Group Cell Differentiation
website Selenoprotein Priority Research Programme
website endocrinology Charité
website Graduiertenkolleg 639