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Research focus:  

Klinische Forschergruppe Zelldifferenzierung und lokale Regulationsysteme
Röntgenring 11, 97070 Würzburg
Mail: kfg.zell@maíl.uni-wuerzburg.de
Url: http://www.uni-wuerzburg.de/zelldifferenzierung/

Scientific members:

   Professors:

   Outside lecturer:

   Scientific assistants:

   Other participating persons and organisations:

Research foci (and basic equipment-based research projects):
Function of Thyroid Hormones, Retinoidsn and Selenoproteins in Differentiation and Cell Defense of epithelial Cells
(Prof. Dr. J. Köhrle)

The Role of the Vitamin D -endocrine System for Bone Formation
and adaptive Remodelling
(Prof. Dr. F. Jakob)

Regulation of gene Expression of the Airway Epithelium
(Prof. Dr. B. Jany)

Results:
S. Brauner, Med. Poliklinik, Abt. Molekulare Innere Medizin, Röntgenring 11, 97070 Würzburg, Germany

http://www.uni-wuerzburg.de/zelldifferenzierung

http://www.uni-wuerzburg.de/spp-selen/


see also scientific publications:

60. Baur A, Köhrle J 1999 Type I 5'-deiodinase is stimulated by iodothyronines and involved in thyroid hormone metabolism in human somatomammotroph GX cells. Eur J. Endocrin. 140:367-370

61. Hoang-Vu C, Bull K, Schwarz I, Krause G, Schmutzler C, Aust G, Köhrle J, Dralle H. 1999 Regulation of CD97 protein in thyroid carcinoma. J Clin. Endocrin. Metab. 84:1104-1109

62. Hoang-Vu C, Bull K, Schwarz I, Holtz J, Schmutzler C, Köhrle J, Dralle H. 1999 Expression of ?death-domain?-receptors and their ligands in benign goitre and thyroid carcinoma. Langenbeck?s Arch. Chir. Suppl. I (Forumband 1999) 197-200

63. Bähr K, Dreher I, Köhrle J 1999 Selenium supplementation by selenium yeast and sodium selenite. analysis of selenium state as well as risks of deficiency and intoxication. Laboratory Medicine 23:594-599

64. Schütze N, Fritsche J, Ebert R, Schneider D, Köhrle J, Andreesen R, Kreutz M, Jakob F 1999 The selenoprotein thioredoxin reductase is expressed in blood monocytes and THP1 human myeloid leukemia cells ? Regulation by 1,25?Dihydroxyvitamin D3 and selenite. Biofactors 10:329-338.

65. Körber C, Schmutzler C, Rendl J, Köhrle, J, Griesser H, Simon D, Reiners C 1999 Increased I-131 uptake in local recurrrence and distant metastases after second treatment with retinoic acid. Clin Nucl Med 24:849-851

66. Mostert V, Dreher I, Köhrle J, Abel J 1999 Transforming growth factor-b1 inhibits expression of selenoprotein P in cultured human liver cells FEBS Letters 460:23-26


67. Hesse-Bähr K, Köhrle J 2000 The influence of the cytokines Il?1β and IFNg on the expression of selenoproteins in the human hepatocarcinoma cell line HepG2. Biofactors 11:83-85

68. Mörk H, Al?Taie OH, Bähr K, Zierer A, Beck K, Scheurlen M, Jakob F, Köhrle J 2000 Inverse mRNA expression of the selenocysteine?containing proteins GI?GPx and SeP in colorectal adenomas compared to adjacent normal mucosa. Nutr. & Cancer 37:108-116

69. Baur A, Bauer K, Jarry H Köhrle J 2000 Effects of proinflammatory cytokines on anterior pituitary 5'-deiodinase type I and type II J. Endocrinology 167: 505-515

70.Mostert V, Wolff S, Dreher I, Köhrle J, Abel J (2001) Identification of a transforming-growth-factor-β-responsive element within the promoter of human selenoprotein P Eur. J. Biochem 268:6176-6181

71. Jakobs TC, Mentrup B, Schmutzler C, Dreher C, Glaser F, Köhrle J 2002 Proinflammatory cytokines inhibit the expression and function of type I 5'?deiodinase in HepG2 hepatocarcinoma cells Eur. J. Endo 146:559-566

72. Brtko J, Bobadova J, Podoba J, Schmutzler C, Köhrle J 2002 Functional thyroid hormone receptors and the type I iodothyronine 5'-deiodinase activity of human toxic adenomas and benign cold nodules
Exp. Clin Endo & Diabetes 110:166-170

73. Schmutzler C, Schmitt TL, Glaser F, Köhrle J, Loos U 2002 The promoter of the human sodium/iodide-symporter gene responds to retinoic acid Mol. Cell. Endo. 189:145-155

74. Hoang-Vu C, Boltze C, Poremba C, Dockhorn-Dworniczak B, Köhrle J, Schmutzler C, Rath FW, Dralle H (2002) Expression and regulation of telomerase genes in thyroid carcinoma Int J Oncol 21:265-272

75. Al-Taie O, Seufert J, Mörk H, Treis H, Mentrup B, Thalheimer A, Starostik P, Abel J, Scheurlen M, Köhrle J, Jakob F (2002) A complex repeat structure of the selenoprotein P promoter contains a functionally relevant polymorphism and is unstable under conditions of mismatch repair deficiency Eur. J Hum Genetics 10:499-504

76. Baur A, Buchfelder M, Köhrle J (2002) Expression of 5?-deiodinase enzymes in normal pituitaries and various human pituitary adenomas. Eur. J. Endo. 147:263-268

77. Simon D, Körber C, Krausch M, Segering J, Groth P, Görges, Grünwald, Müller-Gärtner, Schmutzler C, Köhrle J, Röher HD, Reiners C (2002) Clinical impact of retinoids in redifferentiation therapy of advanced Thyroid cancer ? final results of a Pilot study. Eur. J. Nucl. Med. Mol. Imaging 29:775-782

Rewards and prizes:
Berthold Jany, Wissenschaftlicher Förderpreis der Deutschen Gesellschaft für Pneumologie, Wiesbaden 1992, für seine Untersuchungen zur Muzinexpression im Atemwegsepithel

Josef Köhrle, Felix-Hoppe-Seyler-Preis der Deutschen Gesellschaft für Laboratoriumsmedizin, 1993, für seine Untersuchungen zur differenziellen Regulation eukaryontischer Selenoproteine

Dr. C. Schmutzler und Dr. T. Jakobs: European Merck von Basedow Thyroid Research Prize;

Dr. N. Schütze: von Recklinghausen-Preis der Deutschen Gesellschaft für Endokrinologie

Dr. Jochen Seufert: Schöller-Junkmann-Preis der Deutschen Gesellschaft für Endokrinologie 1998 für seine im Rahmen eines Forschungsstipendiums in Boston (Labor Prof. J. Habener) durchgeführten Arbeiten zum Thema β-Transkriptionsfaktor CCAAT/Enhancer-bindung Protein β (C/EBPβ) - Ein zentraler Mediator der glukotoxischen Inhibition der Insulin Gen Expression in vitro und in vivo.

Dr. Jochen Seufert: Frerichs-Preis der Deutschen Gesellschaft für Innere Medizin 1999 für die Arbeit Die Bedeutung direkter Effekte von Leptin am endokrinen Pankreas für die Bedeutung des adipogenen Diabetes mellitus.
several Poster Prizes at national and international meetings

Links:
website DFG Clinical Research Group Cell Differentiation
website DFG Priority Research Programme 1087 Selenoprotein
website Institut Experimentelle Endokrinologie Charité