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Third-party-funded project

Title:
Analysis of neuromuscular insufficency in rotator cuff disease

Project management at the University of Würzburg:

Participating scientists:

Abstract:
Molecular genetic markers of denervation (expression of fetal Acetylcholine receptor) and immunhistochemical findings are evaluated in biopsies of human rotator cuff and deltoid muscles of patients suffering from subacromial pain. These parameters are correlated to clinical and neurophysiological findings.
In biopsies (supraspinatus and deltoid muscle) of 265 patients suffering from rotator cuff disease in a surprising high percentage (63.7%) markers of chronic denervation were found. The deltoid muscle was involved especially in massive tears.

Key words:
    neuromuscular insufficiency
    muscle atrophy
    rotator cuff
    subacromial pain
    fetal acetylcholine receptor

Projekt period: from 07.2000 to 06.2003

Funding institution:
Landeshaushalt Wissenschaftsministerium
Bund