Forschungsbericht

Interdisziplinäres Zentrum für Klinische Forschung

Research foci (and basic equipment-based research projects):

Interdisciplinary biomedical-clinical research has a long tradition at the Unversity of Würzburg. In...

Third-party-funded project:

(see german version)
Role of the transcription factor Blimp-1/PRDI-BF1 in terminal differentiation of B lymphocytes and in the pathogenesis of the Common Variable Immunodeficiency syndrome
Phänotypical and functional characterization of dendritic cells of the decidua in first trimester human pregnancy
The role of the innate immune response (activation of dendritic cells and γ/δ T cells) in aberrant immune reactions during acute viral infections of infants
Studies on the mechansms of inflammation induced by polymicrobial infections employing the adult periodontitis model
Immunemodulation of stromal stem cells
The influence of heterotopic ossification by ionizing radiation. The mechanism of interaction between ionizing irradiation and the BMP (bone morphogenic protein) induced ossification.
Interaction of Neisseria meningitidis with human dendritic cells: mechanisms and genetic susceptibility
Tumorvaccination using dendritic cells: impact of dendritic cell subsets, maturation inducing stimuli and IL-2.
Pathogenesis of Lyme arthritis: Interaction of synovial cells with Borrelia burgdorferi
Regulation of (seco-) steroidbiosynthesis in monocytes and macrophages by basal transcription factors
Affective disorders and immunoneuronal plasticity: Studies on the function of WKL1, a novel candidate gene for bipolar affective and catatonic disorders
Mechanisms of antigen-recognition by gamma/delta T lymphocytes
Chemoimmunotherapy for melanoma with dacarbazine (DTIC) and dinitrochlorbenzene (DNCB): characterization of the involved mechanisms.
Genomic Instability
The regulation of TRAIL sensitivity in primary keratinocytes
Colorectal Carcinogenesis and oxidative stress - The role of selenium-dependent antioxidative defense systems in colorectal carcinogenesis
Set up and optimization of a tumour tissue bank for the characterization of colorectal carcinoma
Histopathological examination of resected colorectal carcinoma specimens.
Molecular- and cytogenetic characterisation of the colorectal carcinoma
Colorectal Carcinogenesis and oxidative stress - The role of selenium-dependent antioxidative defense systems in colorectal carcinogenesis
Culturing and characterization of normal colon epithelial, adenoma and carcinoma cells to establish an in vitro adenoma carcinoma cell culture model
In situ characterisation of cellular immune responses to solid tumors: from priming to effector function
(see german version)
Generation of proliferation-regulated hematopoietic progenitor cells by transfecting different interleukin-2 receptor chains
(see german version)
characterization of signal transduction in autoreactive T-cells after stimulation with oligomerized T-cell receptor epitopes in models for demyelinating autoimmune diseases
Control of neuritogenic activity of PNS-specific T cells by antigen recognition and costimulation in transgenic mouse models.
Reduction of immunogenicity of human insulin producing pancreatic β-cells by specific suppression of autoantigenic glutamic acid decarboxylase (GAD) expression
Analysis of neuromuscular insufficency in rotator cuff disease
Modulation of the B-cell repertoire in autoimmune diseases
(see german version)
(see german version)
Tolerance mechanisms after orthotopic rat liver transplantation: Functional and molecular biological characterization of intrahepatic CD4+ T lymphocytes
Antigen-specific modulation of T cell alloreactivity by MHC derived peptides and their analogues to induce T cell tolerance after allogeneic transplantation
Therapy of IDDM with microencapsulated porcine islets of Langerhans - Improvement of the xenograft and its long-term function
Effect of ischaemia and reperfusion induced oxidative stress on the formation of transplant vasculopathy in the heterotopic rat model.
Pulmonary hypertension and right heart failure: Determinants of right ventricular remodeling and potential therapeutic approaches
Functional analysis of NO/cGMP- and PG-E1/cAMP-regulated signaling pathways in platelets and their precursor cells in chronic myeloid leukemia.
Effects of novel estrogen receptor ligands on the myocardium
The influence of androgens (and estrogens) on the cardiovascular system
The role of growth factors and neurotrophic factors as signaling molecules for the interaction between mesenchyme, vascular system and sensory epithelium of the cochlea
Identification of cardovascular risk factors in type 2 diabetics with chronic renal failure
(see german version)
Quantitative non-invasive measurement of estrogen receptor status and receptor availability of the myocardium with positron emission tomography (PET) using 16α-[18F]Fluorestradiol-17β (FES).
Comparison of ³¹P-MR-spectroscopy and ²³Na-MR-tomography versus positron emission tomography for assessment of myocardial viability
(see german version)
Functional diagnostic of vascular diseases of the retina with multifocal electroretinogram and NMR
Functional characterisation of tumors during radiation therapy with Magnetic Resonance Imaging
Influence of Nitric Oxide on Microvascular Remodeling and Angiogenesis after Myocardial Ischemia in vivo
Set-up of an interdisziplinary group for microarray applications