The role of dendritic cells and chemokines in the regulation of the immune response to Leishmania parasites
Project management at the University of Würzburg:
The course of infections with parasites of the species Leishmania is determined by the type of the T helper cell-mediated immune response, in particular the pattern of lymphokines released by these T helper cells. Macrophages and dendritic cells are of central importance for the uptake of parasites and the presentation of parasite antigen to specific T cells. Recently we provided evidence that not only the lymphokine profile but also the pattern of chemokine expression correlates with the outcome of Leishmania infection. However, the kinetics of chemokine expression in the course of infection is largely unknown. Furthermore, there is little information about the effects of chemokines on the functions of dendritic cells infected with Leishmania or other pathogens. Therefore, the following aspects are being analyzed: (i) The kinetics of the chemokine/chemokine receptor expression in the course of infection, (ii) the effect of chemokines on the antigen-presentation functions of dendritic cells and the rate of dendritic cell infection with parasites, and (iii) the effect of Leishmania infection on the expression of chemokines and chemokine receptors by dendritic cells. The results of the study will advance the knowledge of the immunoregulation of infections by dendritic cells.
from 01.2001 to 12.2003
- Berberich C., Strittmatter W., Moll H..
(2002). Dendritic cell-based vaccination against tumors and infectious diseases. (monograph)
- Ritter U., Moll H..
(2000). Monocyte chemotactic protein-1 stimulates the killing of Leishmania major by human monocytes, acts synergistically with IFN-gamma and is antagonized by IL-4. Eur. J. Immunol. 30: 3111, (scientific article)
- Moll H..
(2000). The role of dendritic cells at the early stages of Leishmania infection. Adv. Exp. Med. Biol. 479: 163, (scientific article)
- Ponte-Sucre A., Mendoza-Léon A., Moll H..
(2001). Experimental leishmaniasis: synergistic effect of ion channel blockers and interferon-gamma on the clearance of Leishmania major by macrophages. Parasitol. Res. 87: 27, (scientific article)
- Ponte-Sucre A., Figarella K., Moll H..
(2001). Experimental leishmaniasis: the glibenclamide-triggered decrease in parasite growth correlates with changes in macrophage features. Immunopharmacol. Immunotoxicol. 23: 477, (scientific article)
- Ramírez J.R., Gilchrist K., Sepulveda J.C., Moll H., Soldati D., Berberich C..
(2001). Attenuated Toxoplasma gondii ts-4 mutants engineered to express the Leishmania antigen KMP-11 elicit a specific immune response in BALB/c mice. Vaccine 20: 455, (scientific article)
- Moll H., Berberich C..
(2001). Dendritic cells as vectors for vaccination against infectious diseases. Int. J. Med. Microbiol. 291: 323, (scientific article)
- Moll H., Berberich C..
(2001). Dendritic cell-based vaccination strategies: induction of protective immunity against leishmaniasis. Immunobiol. 204: 659, (scientific article)
- Ponte-Sucre A., Heise D., Moll H..
(2001). Leishmania major lipophosphoglycan modulates the phenotype and inhibits migration of murine Langerhans cells. Immunology 104: 462, (scientific article)
- Moll H., Scharner A., Kämpgen E..
(2002). Increased interleukin (IL) 4 receptor expression and IL-4-induced decrease of IL-12 production by Langerhans cells infected with Leishmania major. Infect. Immun. 70: 1627, (scientific article)
- Eisert V., Münster U., Simon M.M., Moll H..
(2002). The course of Leishmania major infection in mice lacking granzyme-mediated mechanisms. Immunobiol. 205: 314, (scientific article)
- Grunewald S.M., Teufel M., Bröcker E.B., Major T., Moll H., Erb K.J..
(2002). Infection with influenza A virus leads to flu antigen-induced cutaneous anaphylaxis in mice. J. Invest. Dermatol. 118: 645-651, (scientific article)
- Erb K.J, Trujillo C., Fugate M., Moll H..
(2002). Infection with the helminth Nippostrongylus brasiliensis does not interfere with the efficient elimination of Mycobacterium bovis BCG from the lung of mice. Clin. Diagn. Lab. Immunol. 9: 727, (scientific article)
- Moll H..
(2002). Combating infectious diseases with dendritic cells. Immunol. Letters (im Druck), (scientific article)