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Third-party-funded project

Title:
The role of dendritic cells and chemokines in the regulation of the immune response to Leishmania parasites

Project management at the University of Würzburg:

Participating scientists:

Abstract:
The course of infections with parasites of the species Leishmania is determined by the type of the T helper cell-mediated immune response, in particular the pattern of lymphokines released by these T helper cells. Macrophages and dendritic cells are of central importance for the uptake of parasites and the presentation of parasite antigen to specific T cells. Recently we provided evidence that not only the lymphokine profile but also the pattern of chemokine expression correlates with the outcome of Leishmania infection. However, the kinetics of chemokine expression in the course of infection is largely unknown. Furthermore, there is little information about the effects of chemokines on the functions of dendritic cells infected with Leishmania or other pathogens. Therefore, the following aspects are being analyzed: (i) The kinetics of the chemokine/chemokine receptor expression in the course of infection, (ii) the effect of chemokines on the antigen-presentation functions of dendritic cells and the rate of dendritic cell infection with parasites, and (iii) the effect of Leishmania infection on the expression of chemokines and chemokine receptors by dendritic cells. The results of the study will advance the knowledge of the immunoregulation of infections by dendritic cells.

Key words:
    Infection
    Parasites
    Monocytes
    Dendritic cells
    Chemokines

Projekt period: from 01.2001 to 12.2003

Funding institution:
DFG

Publications: