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Third-party-funded project

Title:
Familial breast and ovarian cancer, multicenter study of the Deutsche Krebshilfe

Project management at the University of Würzburg:

• Prof. Dr. Bernhard H.F. Weber ,Tel: 888-4062,Fax: 888-4069,Mail: bweb@biozentrum.uni-wuerzburg.de

Participating scientists:

• AIP Ines Bendig
• Dr. med. Dagmar Fuchs
• Dr. med. Heidrun Luck
• Arzt Jörg Schröder

Abstract:
As part of a multicenter study supported by the German Mildred Scheel foundation we have established an interdisciplinary counseling setting for members of breast and/or ovarian cancer families. We offer simultaneous counseling by a team consisting of a geneticist, a gynecologist and a psycho-oncologist.

Key words:
    BRCA1, BRCA2 genes

Projekt period: from 12.1999 to 05.2000

Funding institution:
Sonstige Stiftung ( Deutsche Krebshilfe ) ,Granting date: 15.11.1999

Preceding project:
DKH-70-2001-1

Publications:

• Weber BHF, Brohm M, Stec I, Backe J, Caffier H. (1996). A somatic truncating mutation in BRCA2 in a sporadic breast tumor. Am J Hum Genet 59, 962-964, (scientific article)
• Hofferbert S, Brohm M, Weber BHF. (1998). Search for TSG101 germline mutations in BRCA1/BRCA2-negative breast/ovarian cancer families. Cancer Genetics and Cytogenetics 102, 86-87, (scientific article)
• Backe J, Hofferbert S, Skawran B, Dörk T, Stuhrmann M, Karstens JH, Untch M, Meindl A, Burgemeister R, Chang-Claude J, Weber BHF. (1999). Frequency of BRCA1 mutation 5382insC in German breast cancer patients. Gynecol Oncol 72: 402-406, (scientific article)
• Breast Cancer Linkage Consortium. (1999). Cancer risks in BRCA2 mutation carriers. J Natl.Cancer Inst 91: 1310-1316, (scientific article)
• Hofferbert S, Worringen U, Backe J, Rückert E-M, White K, Faller H, Grimm T, Caffier H, Chang-Claude J, Weber BHF. (2000). Interdisciplinary counselling for familial breast/ovarian cancer in Germany: a study of patient perceptions and decision making. Genetic Counselling 11: 127-146, (scientific article)
• Meindl A and the German Consortium for Hereditary Breast and Ovarian Cancer. (2002). Comprehensive analysis of 989 patients with breast or ovarian cancer provides BRCA1 and BRCA2 mutation profiles and frequencies for the German population. Int J Cancer 97:472-480, (scientific article)

Links:
Publication 48
Publication 59
Publication 77
Publication 83
Publication 90
Publication 104