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Third-party-funded project

Title:
Graduate College 639
Molecular and Structural Basis of Tumor Instability

Project management at the University of Würzburg:

• Prof. Dr. med. Hans Konrad Müller-Hermelink , Sprecher,Tel: 0931/201-477 76,Fax: 0931/201-474 40,Mail: path062@mail.uni-wuerzburg.de
• Prof. Dr. med. Manfred Gessler , Stellv. Sprecher,Tel: 0931/888-41 59,Fax: 0931/888-70 38,Mail: gessler@biozentrum.uni-wuerzburg.de

Participating scientists:

• Prof. Dr. med. Ricardo Benavente ,Tel: 0931/888-42 54,Fax: 0931/888-42 52,Mail: benavente@biozentrum.uni-wuerzburg.de
• Dr. med. Axel Greiner ,Tel: 0931/201-477 85,Fax: 0931/201-474 40,Mail: ag@axel-greiner.de
• Dr. rer. nat. Robert Hock ,Tel: 0931/888-42 64,Fax: 0931/888-42 52,Mail: rhock@biozentrum.uni-wuerzburg.de
• Prof. Dr. med. Franz Jakob ,Tel: 0931/803-15 84,Fax: 0931/803-12 09,Mail: f-jakob.klh@mail.orthopaedie.uni-wuerzburg.de
• Dr. med. vet. Burkhard Kneitz ,Tel: 0931/888-41 46,Fax: 0931/888-41 50,Mail: bkneitz@biozentrum.uni-wuerzburg.de
• Prof. Dr. rer. nat. Josef Köhrle ,Tel: 0931/201-71 000,Fax: 0931/201-71 070,Mail: j.koehrle@mail.uni-wuerzburg.de
• Dr. med. German Ott ,Tel: 0931/201-477 92,Fax: 0931/201-474 40,Mail: path042@mail.uni-wuerzburg.de
• Prof. Dr. rer. nat. Manfred Schartl ,Tel: 0931/888-41 49,Fax: 0931/888-41 50,Mail: phch1@biozentrum.uni-wuerzburg.de
• Prof. Dr. rer. nat. Ulrich Scheer ,Tel: 0931/888-42 51,Fax: 0931/888-42 52,Mail: scheer@biozentrum.uni-wuerzburg.de
• Prof. Dr. rer. nat. Edgar Serfling ,Tel: 0931/201-474 29,Fax: 0931/201-474 40,Mail: path015@mail.uni-wuerzburg.de
• Prof. Dr. med. Helga Stopper ,Tel: 0931/201-48 427,Fax: 0931/201-48 446,Mail: stopper@toxi.uni-wuerzburg.de

Abstract:
We investigate the progressive destabilization of the genome, which is the hallmark of malignant tumors. Our approach comprises established genetic instability syndromes, such as microsatelite and chromosomal instability, but also structural aberrations of genes, chromosome domains, structural nucleoproteins, and chromatin organizers. For this enlargened definition we have coined the term "Tumorinstability". In our eyes "Tumorinstability" is a multifactorial process that progresses in a pleyotropic fashion and leads to global disorder of the spatial organization of the entire cell nucleus. The scientific groups constituting our graduate college are interested in various factors and mechanisms of tumorinstability and contribute diverse experimental aproaches. By a concerted action we are aiming at the composition of an integrated picture of the entire process, which combines aspects of basic sciences, animal models, and clinical oncology. Our efforts are grouped into three main areas of reasearch, which are interlinked by bridging projects and shared methodology.

Key words:
    cancer
    tumor
    genomic instability
    DNA damage
    oncogenes
    tumor suppressor genes

Projekt period: from 10.2000 to 10.2003

Funding institution:
DFG ,Granting date: 27.04.2000

Links:
GK639 homepage