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Forschungsschwerpunkt:  

Lehrstuhl für Haut- und Geschlechtskrankheiten
Josef-Schneider-Str.2, 97080 Würzburg
Mail: gillitzer_r@haut.uni-wuerzbrurg.de
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Forschungsschwerpunkte (und Projekte auf Basis der Grundausstattung):
1) Wundheilungsforschung
2) Pathogenese der Psoriasis
3) Rolle der Chemokine in Entzündungsreaktionen der Haut

Ergebnisse:
KLEINE-LOWINSKI K, GILLITZER R, KÜHNE-HEID R, RÖSL F: Monocyte-chemoattractant proetin-1 (MCP-1) gene expression in cervical intraepithelial neoplasias and cervical carcinoma. Int J Cancer 82(1):6, 1999
R. GILLITZER equal first author

GOEBELER M, KILIAN K, GILLITZER R, KUNZ M, YOSHIMURA T, BRÖCKER EB, RAPP UR, LUDWIG S: The MKK6/p38 stress kinase cascade is involved in TNF-induced activation of endothelial cells. Blood 93:857-865, 1999

YOSHIMURA T, TAKEYA M, OGATA H, YAMASHIRO S, MODI WS, GILLITZER R. . Molecular cloning of the guinea pig GRO and its rapid expression in the tissues of lipopolysaccharide-injected guinea pig. Int. Arch. Allergy Immunol. 119:101, 1999

HARTMANN A, KUNZ M, KÖSTLIN S, GILLITZER R, TOKSOY A, BRÖCKER EB, KLEIN CE: Hypoxia-induced up-regulation of Angiogenin in human malignant melanoma. Cancer Research 59:1578-1583, 1999

KUNZ M, TOKSOY A; GOEBELER M, ENGELHARDT E, BRÖCKER EB, GILLITZER R. High expression of the lymphoattractant CXC chemokine Mig is associated with strong infiltration of T cells in human malignant melanoma. J Path 189:552-558, 1999

KUNZ M, HARTMANN A, FLORY E, TOKSOY A, KOCZAN D, THIESEN HJ, RAPP UR, BRÖCKER EB, GILLITZER R. Hypoxia-induced upregulation of interleukin-8 in human malignant melanoma: A potential mechanism for high tumor aggressiveness. Am J Path 155:753-763, 1999

TRAUTMANN A, TOKSOY A, ENGELHARDT E, BRÖCKER EB, GILLITZER R: Mast cell involvement in normal human skin wound healing: expression of monocyte chemoattractant protein-1 is correlated with recruitment of mast cells which synthesize interleukin-4 in vivo. J Path 190:100-106, 2000

SALAIZO-SUAZO N, VOLKOW P, PEREZ-TAMAYO R, MOLL H, GILLITZER R, PEREZ-TORRES A, PEREZ-MONTFORT R, DELGADO DOMINGUEZ J, VELASCO_CASTREJON O, CRIPPA M, BECKER I. Treatment of two patients with diffuse cutaneus Leishmaniasis caused by Leishmania mexicana modified the immunohistological profile but not the disease outcome. Trop Med Inter Health 4:801-811, 2000

KÖNIG A, KRENN V. TOKSOY A, GERHARD N, GILLITZER R. Mig, GROalpha and RANTES messenger RNA expression in lining layer, infiltrates and different leukocyte populations of synovial tissue from patients with rheumatoid arthritis, psoriatic arthritis and osteoarthritis. Virchows Archiv 436:449-458, 2000


ECK M, SCHMAUSSER B, TOKSOY A, SCHELLER K, KRAUS M, MENZEL T, MÜLLER-HERMELINK HK, GILLITZER R. C-X-C chemokines Groa/Il-8 and IP-10/Mig in Helicobacter pylori gastritis. Clin Exp Immunol 122:192-199, 2000

GOEBELER M, GILLITZER R, KILIAN K, UTZEL K, BRÖCKER EB, RAPP UR, LUDWIG S. Multiple signaling pathways regulate NF-kB-dependant transcription of the monocyte chemoattractant proetin-1 gene in primary endothelial cells. Blood 97:46-55, 2001

GOEBELER M, TRAUTMANN A, TOKSOY A, BRÖCKER E-B, VOSS A, GILLITZER R. Differential and sequential expression of multiple chemokines regulates effector cell recruitment during elicitation of allergic contact dermatitis. Am J Pathol 158:431-440, 2001

SPANDAU U, BRÖCKER EB, KÄMPGEN E, GILLITZER R. CC and CXC chemokines are differentially expressed in Erythema multiforme. Arch Dermatol 138:1027-1033, 2002

PASPARAKIS M, COURTOIS G, HAFNER M, SCHMIDT-SUPPRIAN M, NENCI A, TOKSOY A, KRAMPERT M, GOEBELER M, GILLITZER R, ISRAEL A, KRIEG T, RAJEWSKY K, HAASE I. TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2. Nature 417:861-866, 2002


Übersichtsartikel:


GILLITZER R. TOKSOY A, VOSS A. The role of chemokines during human wound healing. Zentralblatt für Chirurugie S1,56-60, 2000

GILLITZER R. Inflammation in human skin: a model to study chemokine-mediated leukocyte migration in vivo. J Path 194:393-394, 2001

GILLITZER R, GOEBELER M. Chemokines in cutaneous wound healing. J Leuc Biol
69:513-521, 2001

GILLITZER R. Modern Wound management. Hautarzt 53:130-145, 2002-11-24

Auszeichnungen und Preise:
Theodor Nasemann Stipendium

Ausstattung:
Labor mit molekularbiologisch relevantem Handwerkzeug, Isotopenlabor, Kryostat, Forschungsmikroskop